505-90-8Relevant articles and documents
Bioactive constituents from the leaves of Croton tiglium
Duan, Li-Kun,Feng, Jin-E.,He, Hong-Ping,Huang, Chun-Qiu,Jiang, Zhi-Yong,Li, Xiao-Fei,Li, Yuan,Liu, Chun-Jiang,Shi, Sheng-Li,Zuo, Ai-Xue
, p. 65 - 72 (2022/03/15)
Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral
Alkenyl Carbonyl Derivatives in Enantioselective Redox Relay Heck Reactions: Accessing α,β-Unsaturated Systems
Zhang, Chun,Santiago, Celine B.,Kou, Lei,Sigman, Matthew S.
supporting information, p. 7290 - 7293 (2015/06/30)
A highly enantioselective and site-selective Pd-catalyzed arylation of alkenes linked to carbonyl derivatives to yield α,β-unsaturated systems is reported. The high site selectivity is attributed to both a solvent effect and the polarized nature of the carbonyl group, both of which have been analyzed through multidimensional analysis tools. The reaction can be performed in an iterative fashion allowing for a diastereoselective installation of two aryl groups along an alkyl chain.
TPAP-catalyzed direct oxidation of primary alcohols to carboxylic acids through stabilized aldehyde hydrates
Schmidt, Andrea-Katharina C.,Stark, Christian B. W.
supporting information; experimental part, p. 4164 - 4167 (2011/10/08)
We present a simple, mild, and highly effective method for the direct conversion of primary alcohols to carboxylic acids. TPAP serves as the catalyst, and NMO?H2O plays a dual role, acting as the co-oxidant and as a reagent for aldehyde hydrate stabilization. This previously unknown stabilizing effect of geminal diols by N-oxides is the key for the efficiency of the overall transformation.