19259-70-2

Basic information

• Product Name: HEXYLDIPHENYLPHOSPHINE OXIDE
• Synonyms: HEXYLDIPHENYLPHOSPHINE OXIDE
• CAS NO: 19259-70-2
• Molecular Formula: C₁₈H₂₃OP
• Molecular Weight: 0
• Mol File: 19259-70-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 384.2°C at 760 mmHg
• Flash Point: 186.1°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 9.22E-06mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: HEXYLDIPHENYLPHOSPHINE OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HEXYLDIPHENYLPHOSPHINE OXIDE(19259-70-2)
• EPA Substance Registry System: HEXYLDIPHENYLPHOSPHINE OXIDE(19259-70-2)

Safety Data

• Hazardous Substances Data: 19259-70-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H23OP/c1-2-3-4-11-16-20(19,17-12-7-5-8-13-17)18-14-9-6-10-15-18/h5-10,12-15H,2-4,11,16H2,1H3

Upstream product

• 592-41-6 1-hexene 
• 4559-70-0 Diphenylphosphine oxide 
• 829-85-6 diphenylphosphane 
• 111-25-1 1-bromo-hexane 
• 36838-04-7 α-Oxo-phenylmethan-diphenylphosphin 
• 70127-50-3 diphenyl(2-hydroxyphenylmethyl)phosphine oxide 
• 111-14-8 oenanthic acid 
• 3839-35-8 4-methylbenzenesulfonic acid n-hexylester 
• 6172-92-5 Hexyl-phosphonsaeure-dimethylester 
• 100-58-3 phenylmagnesium bromide 
• 1079-66-9 chloro-diphenylphosphine 
• 1015-38-9 diphenylphosphinodithioic acid 
• 1499-21-4 Diphenylphosphinic chloride 
• 542-69-8 1-iodo-butane 

Downstream Products

• 201872-03-9 6-Diphenylphosphinoylundecan-5-one 
• 201872-04-0 4-Diphenylphosphinoyl-2-methylnonan-3-one 
• 96302-81-7 (2RS,5SR; E)-5-diphenylphosphinoyldec-3-en-2-ol 
• 96302-81-7 (2RS,5RS; E)-5-diphenylphosphinoyldec-3-en-2-ol 
• 98754-01-9 (4RS,5SR; E)-4-acetoxy-5-diphenylphosphinoyldec-2-ene 
• 98754-03-1 (2E,4Z)-5-diphenylphosphinoyldeca-2,4-diene 
• 98754-02-0 (2E,4E)-5-diphenylphosphinoyldeca-2,4-diene 
• 96302-71-5 (4RS,5SR; E)-2-acetoxy-5-diphenylphosphinoyldec-3-ene 
• 96302-71-5 (2RS,5RS; E)-2-acetoxy-4-diphenylphosphinoyldec-3-ene 
• 98753-99-2 (2RS,5SR; E)-5-diphenylphosphinoyldec-3-en-2-yl 4-nitrobenzoate 
• 98753-99-2 (2RS,5RS; E)-5-diphenylphosphinoyldec-3-en-2-yl 4-nitrobenzoate 
• 98753-98-1 (4RS,5SR; E)-5-diphenylphosphinoyldec-2-en-4-yl nitrobenzoate 
• 98753-98-1 (4RS,5RS; E)-5-diphenylphosphinoyldec-2-en-4-yl nitrobenzoate 
• 59627-83-7 (E)-2-Diphenylphosphinoyl-3-methyloct-3-en 

Relevant articles and documents

Visible light induced hydrophosphinylation of unactivated alkenes catalyzed by salicylaldehyde

An air and water insensitive visible light induced hydrophosphinylation of unactivated alkenes is reported. A small amount of a simple and cheap compound, salicylaldehyde, is used as a photosensitizer. The reaction is carried out in a basic aqueous solution which enables the deprotonated salicylaldehyde to show visible light absorption.

Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action

Here we report the synthesis and biological evaluation of a series of new 2-hydroxybenzylphosphonium salts (QPS) with antimicrobial and antitumor dual action. The most active compounds exhibit antimicrobial activity at a micromolar level against Gram-positive bacteria Sa (ATCC 209p and clinical isolates), Bc (1–2 μM) and fungi Tm and Ca, and induced no notable hemolysis at MIC. The change in nature of substituents of the same length led to a drastic change of biological activity. Self-assembly behavior of the octadecyl and oleyl derivatives was studied. QPS demonstrated self-assembly within the micromolar range with the formation of nanosized aggregates capable of the solubilizing hydrophobic probe. The synthesized phosphonium salts were tested for cytotoxicity. The most potent salt was active against on M?Hela cell line with IC50 on the level of doxorubicin and good selectivity. According to the cytofluorimetry analysis, the salts induced mitochondria-dependent apoptosis.

Preparation method of alkyl phosphorylated substances

The invention discloses a preparation method of alkyl phosphorylated substances. According to the invention, alkyl carboxylic acid is used as a starting material, and raw materials are easy to obtain and are various in types. Products prepared by the method disclosed by the invention are various in types and wide in application; and a part of the products can be prepared into important phosphorus ligands and drug key intermediates through simple reduction. In addition, use of high-toxicity phosphine reagents is avoided in the method, the reaction conditions are mild, operation is simple, the yield of the target product is high, pollution is small, and the reaction operation and post-treatment processes are simple, so that the method is suitable for industrial production.