4-Bromo-5-fluoro-2-nitrobenzoic acid

Base Information

• Chemical Name: 4-Bromo-5-fluoro-2-nitrobenzoic acid
• CAS No.: 1020717-99-0
• Molecular Formula: C7H3BrFNO4
• Molecular Weight: 264.008
• Hs Code.: 2916399090
• Mol file: 1020717-99-0.mol

Synonyms:2-Nitro-4-Bromo-5-fluorobenzoic acid;Benzoic acid, 4-bromo-5-fluoro-2-nitro-;

Chemical Property of 4-Bromo-5-fluoro-2-nitrobenzoic acid

Chemical Property:

• Boiling Point: 367.576 °C at 760 mmHg
• Flash Point: 176.104 °C
• PSA: 83.12000
• Density: 1.967 g/cm³
• LogP: 2.71780

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-5-fluoro-2-nitrobenzoic acid

There total 1 articles about 4-Bromo-5-fluoro-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

4-bromo-3-fluorobenzoic acid (153556-42-4) → 4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃; for 18h;

Reference yield: 96.0%

4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0) → 3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; at 90 ℃; for 3h;

Reference yield: 95.0%

2,4-difluorophenol (367-27-1) + 4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0) → 4-bromo-5-(2,4-difluorophenoxy)-2-nitrobenzoic acid (1446236-60-7)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 110 ℃; for 1h;

upstream raw materials:

4-bromo-3-fluorobenzoic acid

Downstream raw materials:

methyl 4-bromo-5-fluoro-2-nitrobenzoate

2-amino-4-bromo-5-fluorobenzoic acid monohydrochloride

4-bromo-2-((1-carboxyethyl)amino)-5-fluorobenzoic acid

4-bromo-5-(2,4-difluorophenoxy)-2-nitrobenzoic acid

Refernces

• 1、 -. "SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS". Page/Page column 113. . Retrieved 2017/07/14.
• 2、 -. "1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS". Page/Page column 42. . Retrieved 2015/02/25.