4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester

Base Information

• Chemical Name: 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester
• CAS No.: 1220886-29-2
• Molecular Formula: C8H5BrFNO4
• Molecular Weight: 278.034
• Mol file: 1220886-29-2.mol

Synonyms:4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester;Methyl 4-broMo-5-fluoro-2-nitrobenzoate;3-Bromo-2-fluoro-6-nitro-benzoic acid methyl ester

Chemical Property of 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester

Chemical Property:

• Boiling Point: 337.6±42.0 °C(Predicted)
• PSA: 72.12000
• Density: 1.742±0.06 g/cm3(Predicted)
• LogP: 2.80620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-bromo-5-fluoro-2-nitrobenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester

There total 7 articles about 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0) + methyl iodide (74-88-4) → methyl 4-bromo-5-fluoro-2-nitrobenzoate (1220886-29-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 2.25h;

Reference yield: 86.0%

methyl 4-bromo-3-fluorobenzoate (849758-12-9) → methyl 4-bromo-5-fluoro-2-nitrobenzoate (1220886-29-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c00347

Reference yield: 53.0%

4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 4-bromo-5-fluoro-2-nitrobenzoate (1220886-29-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; acetonitrile; at 0 - 20 ℃; for 2h;

upstream raw materials:

diazomethane

4-bromo-5-fluoro-2-nitrobenzoic acid

methyl iodide

4-bromo-3-fluorobenzoic acid

Downstream raw materials:

methyl 2-nitro-4-bromo-5-hydroxybenzoate

2-amino-4-bromo-5-fluorobenzaldehyde

ethyl 3-{[(benzyloxy)carbonyl]amino}-7-bromo-6-fluoroquinoline-2-carboxylate

3-{[(benzyloxy)carbonyl]amino}-6-fluoro-7-vinylquinoline-2-carboxylic acid

Refernces

• 1、 Lapointe, Guillaume,Skepper, Colin K.,Holder, Lauren M.,Armstrong, Duncan,Bellamacina, Cornelia,Blais, Johanne,Bussiere, Dirksen,Bian, Jianwei,Cepura, Cody,Chan, Helen,Dean, Charles R.,De Pascale, Gianfranco,Dhumale, Bhavesh,Fisher, L. Mark,Fulsunder, Mangesh,Kantariya, Bhavin,Kim, Julie,King, Sean,Kossy, Lauren,Kulkarni, Upendra,Lakshman, Jay,Leeds, Jennifer A.,Ling, Xiaolan,Lvov, Anatoli,Ma, Sylvia,Malekar, Swapnil,McKenney, David,Mergo, Wosenu,Metzger, Louis,Mhaske, Keshav,Moser, Heinz E.,Mostafavi, Mina,Namballa, Sunil,Noeske, Jonas,Osborne, Colin,Patel, Ashish,Patel, Darshit,Patel, Tushar,Piechon, Philippe,Polyakov, Valery,Prajapati, Krunal,Prosen, Katherine R.,Reck, Folkert,Richie, Daryl L.,Sanderson, Mark R.,Satasia, Shailesh,Savani, Bhautik,Selvarajah, Jogitha,Sethuraman, Vijay,Shu, Wei,Tashiro, Kyuto,Thompson, Katherine V.,Vaarla, Krishniah,Vala, Lakhan,Veselkov, Dennis A.,Vo, Jason,Vora, Bhavesh,Wagner, Trixie,Wedel, Laura,Williams, Sarah L.,Yendluri, Satya,Yue, Qin,Yifru, Aregahegn,Zhang, Yong,Rivkin, Alexey. "Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria". . p. 6329 - 6357. Retrieved 2021/06/01.
• 2、 -. "QUINOLONE DERIVATIVES AS ANTIBACTERIALS". . . Retrieved 2016/04/20.