1374208-42-0

Basic information

• Product Name: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID
• Synonyms: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID;2-amino-4-bromo-5-fluorobenzoicacidhydrochloride;EOS-62377
• CAS NO: 1374208-42-0
• Molecular Formula: C₇H₅BrFNO₂
• Molecular Weight: 234.0225032
• Mol File: 1374208-42-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 353.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.877±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID(1374208-42-0)
• EPA Substance Registry System: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID(1374208-42-0)

Safety Data

• Hazardous Substances Data: 1374208-42-0(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID is a chemical compound with the molecular formula C7H5BrFNO2. It is a derivative of benzoic acid with a bromine and a fluorine atom attached to the benzene ring, as well as an amino group at the 2-position. 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID is commonly used in the pharmaceutical and chemical industries as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has potential applications in the development of new drugs and can also be used as a reagent in laboratory research and testing. The compound's specific properties and potential uses make it an important and valuable component in chemical and pharmaceutical processes.

Upstream product

• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 656-64-4 3-bromo-4-fluoroaniline 
• 1374208-41-9 5-fluoro-6-bromo-1H-indolin-2,3-dione 
• 1374208-40-8 N-(3-bromo-4-fluorophenyl)-2-hydroxyiminoacetamide 
• 1020717-99-0 4-bromo-5-fluoro-2-nitrobenzoic acid 
• 1395493-30-7 2-amino-4-bromo-5-fluorobenzoic acid methyl ester 

Downstream Products

• 1374208-44-2 2,4-dichloro-6-fluoro-7-bromoquinazoline 
• 1643368-58-4 BMS-986142 
• 1643368-58-4 6-fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(R)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide 
• 1643156-20-0 ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate 
• 1643156-18-6 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride 
• 1643156-18-6 4-bromo-2-hydrazinyl-5-fluorobenzoic acid monohydrochloride 
• 1374208-43-1 7-bromo-6-fluoro-1H-quinazoline-2,4-dione 

Relevant articles and documents

KINASE INHIBITORS

Disclosed herein are protein kinase inhibitors, in particular Bruton's tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for preparing them and uses of such protein kinase inhibitors to treat or prevent diseases, disorders and conditions associated with kinase function. In particular, the present invention relates to selective BTK inhibitors.

ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF

The disclosure relates to compounds that act as an allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.