2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID
• CAS No.: 1374208-42-0
• Molecular Formula: C7H5BrFNO2
• Molecular Weight: 234.025
• Hs Code.: 2916399090
• Mol file: 1374208-42-0.mol

Synonyms:2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID;2-amino-4-bromo-5-fluorobenzoicacidhydrochloride

Chemical Property of 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID

Chemical Property:

• Boiling Point: 353.6±42.0 °C(Predicted)
• PKA: 4.37±0.10(Predicted)
• PSA: 63.32000
• Density: 1.877±0.06 g/cm3(Predicted)
• LogP: 2.44980
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-amino-4-bromo-5-fluorobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID

There total 6 articles about 2-AMINO-4-BROMO-5-FLUOROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-amino-4-bromo-5-fluorobenzoic acid methyl ester (1395493-30-7) → 3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield: 96.0%

4-bromo-5-fluoro-2-nitrobenzoic acid (1020717-99-0) → 3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; at 90 ℃; for 3h;

Reference yield: 25.0%

5-fluoro-6-bromo-1H-indolin-2,3-dione (1374208-41-9) → 3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0)

Guidance literature:

5-fluoro-6-bromo-1H-indolin-2,3-dione; With dihydrogen peroxide; sodium hydroxide; at 0 ℃; for 3h;

With hydrogenchloride; at 0 ℃; pH=5;

upstream raw materials:

N-(3-bromo-4-fluorophenyl)-2-hydroxyiminoacetamide

5-fluoro-6-bromo-1H-indolin-2,3-dione

3-bromo-4-fluoroaniline

2-amino-4-bromo-5-fluorobenzoic acid methyl ester

Downstream raw materials:

7-bromo-6-fluoro-1H-quinazoline-2,4-dione

2,4-dichloro-6-fluoro-7-bromoquinazoline

Refernces

• 1、 -. "KINASE INHIBITORS". Page/Page column 98. . Retrieved 2021/10/15.
• 2、 -. "Spiro-substituted pyrimido-cyclic compound, and preparation method and medical application thereof". Paragraph 0250-0252. . Retrieved 2020/12/31.