943635-05-0

Basic information

• Product Name: 4-(N,N-dimethylamino)-2-methylbenzamide
• Synonyms: 4-(N,N-dimethylamino)-2-methylbenzamide
• CAS NO: 943635-05-0
• Molecular Weight: 178.234
• Mol File: 943635-05-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(N,N-dimethylamino)-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N,N-dimethylamino)-2-methylbenzamide(943635-05-0)
• EPA Substance Registry System: 4-(N,N-dimethylamino)-2-methylbenzamide(943635-05-0)

Safety Data

• Hazardous Substances Data: 943635-05-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 52771-13-8 4-amino-2-methylbenzamide 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 50638-50-1 3-methyl-4-bromo-N,N-dimethylaniline 
• 65399-14-6 4-(dimethylamino)-2-methylbenzoic acid 

Downstream Products

• 1462328-58-0 C₁₃H₁₉N₃O 
• 1178884-09-7 6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1242156-99-5 C₁₈H₁₇BrN₂O₂ 
• 1198765-28-4 C₃₄H₃₄N₆O₅ 
• 1462328-86-4 2-(3-chloro-2-(hydroxymethyl)phenyl)-6-(dimethylamino)-3,4-dihydroisoquinolin-1(2H)-one 
• 1462328-78-4 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde 
• 1178884-33-7 6-dimethylamino-3,4-dihydro-2H-isoquinolin-1-one 

Relevant articles and documents

Development of a scalable synthesis of a Bruton's tyrosine kinase inhibitor via C-N and C-C bond couplings as an end game strategy

A scalable and convergent synthesis of a BTK (Bruton's tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, which was prepared via a regioselective cyclization of an isocyanate, mediated by AlCl3. Improved routes to key building blocks were demonstrated by expedient multikilogram productions. The target compound was assembled through a Pd-catalyzed amidation reaction followed by a Suzuki-Miyaura cross-coupling reaction.