1462328-78-4

Basic information

• Product Name: 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde
• Synonyms: 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde
• CAS NO: 1462328-78-4
• Molecular Weight: 328.798
• Mol File: 1462328-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde(1462328-78-4)
• EPA Substance Registry System: 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde(1462328-78-4)

Safety Data

• Hazardous Substances Data: 1462328-78-4(Hazardous Substances Data)

Upstream product

• 943635-05-0 4-(N,N-dimethylamino)-2-methylbenzamide 
• 65399-14-6 4-(dimethylamino)-2-methylbenzoic acid 
• 50638-50-1 3-methyl-4-bromo-N,N-dimethylaniline 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 1178884-33-7 6-dimethylamino-3,4-dihydro-2H-isoquinolin-1-one 
• 64622-16-8 2-bromo-6-chlorobenzaldehyde 
• 108-37-2 1-bromo-3-chlorobenzene 
• 214045-84-8 6-fluoro-3,4-dihydro-2H-isoquinolin-1-one 
• 102422-57-1 1-Fluoro-3-(2-isocyanato-ethyl)-benzene 
• 404-70-6 2-(3-Fluorophenyl)ethylamine 
• 1462328-68-2 C₁₁H₁₄N₄O 
• 619-22-7 3-(dimethylamino)benzaldehyde 
• 1462328-58-0 C₁₃H₁₉N₃O 

Downstream Products

• 1178884-09-7 6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1198765-28-4 C₃₄H₃₄N₆O₅ 
• 1462328-83-1 C₃₄H₃₂N₆O₅ 
• 1462328-86-4 2-(3-chloro-2-(hydroxymethyl)phenyl)-6-(dimethylamino)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Development of a scalable synthesis of a Bruton's tyrosine kinase inhibitor via C-N and C-C bond couplings as an end game strategy

A scalable and convergent synthesis of a BTK (Bruton's tyrosine kinase) inhibitor has been developed. Synthetic routes to key intermediates were explored for the scale-up campaign, especially the process for 6-dimethylaminodihydroisoquinolinone, which was prepared via a regioselective cyclization of an isocyanate, mediated by AlCl3. Improved routes to key building blocks were demonstrated by expedient multikilogram productions. The target compound was assembled through a Pd-catalyzed amidation reaction followed by a Suzuki-Miyaura cross-coupling reaction.