292067-97-1

Basic information

• Product Name: Etoricoxib impurity Q
• Synonyms: Etoricoxib impurity Q;5-chloro-6'-methyl-3-(4-(methylthio)phenyl)-2,3'-bipyridine
• CAS NO: 292067-97-1
• Molecular Formula: C₁₈H₁₅ClN₂S
• Molecular Weight: 326.8431
• Mol File: 292067-97-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Etoricoxib impurity Q(CAS DataBase Reference)
• NIST Chemistry Reference: Etoricoxib impurity Q(292067-97-1)
• EPA Substance Registry System: Etoricoxib impurity Q(292067-97-1)

Safety Data

• Hazardous Substances Data: 292067-97-1(Hazardous Substances Data)

Usage

General Description

Etoricoxib impurity Q is a chemical substance that is used in the production and processing of the pharmaceutical drug etoricoxib. It is classified as an impurity, which means it is a substance that is present in the final drug product at low levels as a result of the manufacturing process. Etoricoxib impurity Q is a byproduct that is formed during the synthesis of etoricoxib and must be carefully controlled and monitored to ensure the safety and efficacy of the final drug product. Its presence in the drug substance needs to be minimized to comply with regulatory standards for pharmaceutical products. Therefore, thorough testing and analysis are carried out during the production process to ensure that levels of Etoricoxib impurity Q are kept within acceptable limits.

Upstream product

• 321913-54-6 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone 
• 38746-92-8 2-[4-(methylsulfanyl)phenyl]acetonitrile 
• 5470-70-2 Methyl 6-methylnicotinate 
• 221615-72-1 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone 
• 50704-42-2 2-chloromalonaldehyde 
• 745050-28-6 2-benzoyloxy-5-chloro-3-[4-(methylthio)phenyl]pyridine 
• 745050-29-7 5-chloro-2-hydroxy-3-[4-(methylthio)phenyl]pyridine 
• 745050-30-0 2,5-dichloro-3-[4-(methylthio)phenyl]pyridine 
• 175883-59-7 5-trimethylstannanyl-2-methylpyridine 

Downstream Products

• 202409-33-4 etoricoxib 
• 1447814-82-5 5-chloro-3-(4-methylthiophenyl)-6'-methyl-[2,3']bipyridine hydrochloride 
• 866336-08-5 thiobutyric acid S-[4-(5-chloro-6'-methyl-[2,3']bipyridinyl-3-yl)phenyl] ester 

Relevant articles and documents

Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.

PROCESS FOR THE SYNTHESIS OF ETORICOXIB

The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).

Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx and Arcoxia

The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 and 4 w