2730-62-3

Basic information

• Product Name: 2-CHLORO-3,3,3-TRIFLUOROPROPENE
• Synonyms: 2-CHLORO-3,3,3-TRIFLUOROPROP-1-ENE;2-CHLORO-3,3,3-TRIFLUOROPROPENE;2-Chloro-3,3,3-trifluoroprop-1-ene 98%;2-Chloro-3,3,3-trifluoroprop-1-ene98%;2-Chloro-3,3,3-trifluoro-1-propene
• CAS NO: 2730-62-3
• Molecular Formula: C₃H₂ClF₃
• Molecular Weight: 130.5
• Mol File: 2730-62-3.mol
• Article Data: 87

Chemical Properties

• Boiling Point: 15°C
• Flash Point: -16∶C
• Appearance: /
• Density: 1.295
• Vapor Pressure: 690mmHg at 25°C
• Refractive Index: 1.334
• CAS DataBase Reference: 2-CHLORO-3,3,3-TRIFLUOROPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3,3,3-TRIFLUOROPROPENE(2730-62-3)
• EPA Substance Registry System: 2-CHLORO-3,3,3-TRIFLUOROPROPENE(2730-62-3)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 23-38
• RIDADR: 3163
• HazardClass: GAS
• Hazardous Substances Data: 2730-62-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-3,3,3-trifluoropropene is used in preparation of trifluoropropyne by dehydrohalogenation in gas phase.

InChI:InChI=1/C3H2ClF3/c1-2(4)3(5,6)7/h1H2

Synthetic route

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With potassium hydroxide; Aliquat 336 In water at 10 - 20℃; Product distribution / selectivity;	97%
With alkali
With potassium hydroxide In ethanol at -10℃;

1,1,1,2,2-pentachloropropane (64240-29-5) + 1,1,1,3,3-pentachloropropane (23153-23-3) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With hydrogen fluoride at 300℃; for 0.001h; Inert atmosphere;	94.9%

1,1,1,2,3-pentachloro-propane (21700-31-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With hydrogen fluoride In water at 400℃; under 750.075 Torr; for 8h; Inert atmosphere;	94.3%
With hydrogen fluoride; fluorinated Cr2O3 at 255℃;
With hydrogen fluoride; chromium(III) oxide at 255℃; under 915.2 Torr; for 0.00416667h; Industry scale;

2,2-dichloro-3,3,3-trifluoropropyl acetate (20411-85-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With zinc In ethanol Heating;	73%

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride; chlorine; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride In 1,1,2-trichloro-2,2-difluoroethane at 132.1℃; under 6000.6 Torr; Product distribution / selectivity;	72.6%
With hydrogen fluoride; diisopropylamine; chromium(III) oxide at 200 - 300℃; under 760.051 Torr; for 0.000569444 - 0.00277778h; Product distribution / selectivity;
With methoxyhydroquinone; hydrogen fluoride; chromium(III) oxide at 243 - 254℃; under 760.051 Torr; for 66.75h; Product distribution / selectivity;

1-Chloro-3,3,3-trifluoro-2-iodopropane → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 1-chloro-3,3,3-trifluoropropene (2730-43-0)

Conditions	Yield
With fluorinated chromia at 200℃; Inert atmosphere;	A 40% B 60%

1,1,1,2,2-pentachloropropane (64240-29-5) + 1,1,1,3,3-pentachloropropane (23153-23-3) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + trans-1,3,3,3-tetrafluoropropene (29118-24-9) + 1-chloro-3,3,3-trifluoropropene (2730-43-0)

Conditions	Yield
With hydrogen fluoride at 300℃; for 0.001h; Time; Inert atmosphere;	A 29.6% B 6.6% C 60%

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-chloro-1,1,1,2-tetrafluoropropane (421-73-8) + 1,1,1,2,3-pentafluoropropane (431-31-2) + 2,3-dichloro-1,1,1-trifluoropropane (338-75-0) + 1-chloro-2,3,3,3-tetrafluoropropane (151771-09-4) + 2-chloro-1,1,1,3-tetrafluoropropane (117970-90-8)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride at 100 - 125℃; under 33082.7 - 39185.2 Torr; for 12h; Product distribution / selectivity;	A n/a B n/a C 53% D n/a E n/a F n/a

1,1,1,2,2-pentachloropropane (64240-29-5) + 1,1,1,3,3-pentachloropropane (23153-23-3) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 1-chloro-3,3,3-trifluoropropene (2730-43-0)

Conditions	Yield
With hydrogen fluoride at 250℃; for 0.00277778h; Temperature; Time; Inert atmosphere;	A 50% B 49.8%

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-chloro-2,3,3-trifluoro-butane (374-06-1)

Conditions	Yield
With hydrogen fluoride; antimonypentachloride; chlorine; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride In 1,1,2-trichloro-2,2-difluoroethane at 133.2℃; under 6000.6 Torr; Product distribution / selectivity;	A 25.5% B 6.6%

2,3-dichloro-3,3-difluoroprop-1-ene (2252-87-1) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With antimony dichloride trifluoride; antimony(III) fluoride
With antimonypentachloride; antimony(III) fluoride at 170℃; for 4h;

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 3,3,3-trifluoroprop-1-yne (661-54-1)

Conditions	Yield
With potassium hydroxide

2,3,3,3-tetrachloropropene (16500-91-7) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
With antimony dichloride trifluoride; antimony(III) fluoride

6-chloro-5-trifluoromethyl-1,6-diazabicyclo<3.1.0>hexane (113036-02-5, 113085-26-0, 120575-10-2, 120575-11-3, 164714-23-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
In Cyclohexane-d12 at 80℃; for 80h; Product distribution; Mechanism;

2,3-dichloro-3,3-difluoroprop-1-ene (2252-87-1) + antimony(III) fluoride (7783-56-4) + antimony dichloride trifluoride → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

Conditions	Yield
at 30℃;

2,3,3,3-tetrachloropropene (16500-91-7) + antimony(III) fluoride (7783-56-4) + 1,2-dichloro-ethane (107-06-2) + antimony dichloride trifluoride → 2-chloro-1,1,1-trifluoropropene (2730-62-3)

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) + potassium hydroxide → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 3,3,3-trifluoroprop-1-yne (661-54-1)

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + (Z)-1-chloro-3,3,3-trifluoro-1-propene (99728-16-2) + 2,3,3,3-tetrafluoro-propene (754-12-1) + 1,1,1,2,2-pentafluoropropane (1814-88-6) + 1,1,1,3,3-Pentafluoropropane (460-73-1) + trans-1,3,3,3-tetrafluoropropene (29118-24-9) + (Z)-1,3,3,3-tetrafluoropropene (29118-25-0) + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0)

Conditions	Yield
With hydrogen fluoride; 2percentCo2O3/Cr2O3, fluorided at 325 - 400℃; Product distribution / selectivity;

...Expand

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2,3,3,3-tetrafluoro-propene (754-12-1) + 1,1,1,2,2-pentafluoropropane (1814-88-6) + 1,1,1,3,3-Pentafluoropropane (460-73-1) + trans-1,3,3,3-tetrafluoropropene (29118-24-9) + (Z)-1,3,3,3-tetrafluoropropene (29118-25-0) + 2-chloro-1,1,1,3-tetrafluoropropane (117970-90-8)

Conditions	Yield
With hydrogen fluoride; 2percentCo2O3/Cr2O3, fluorided at 275℃; Product distribution / selectivity;

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 1,1,1-trifluoropropylene (677-21-4) + 2-chloro-1,1,1,3-tetrafluoropropane (117970-90-8)

Conditions	Yield
With hydrogen fluoride at 140℃; Gas phase;
With hydrogen fluoride at 140℃; Inert atmosphere;

1,1,1-trifluoropropylene (677-21-4) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + (Z)-1-chloro-3,3,3-trifluoro-1-propene (99728-16-2) + 2,3,3,3-tetrafluoro-propene (754-12-1) + (Z)-1,2-dichloro-3,3,3-trifluoropropene (25062-10-6) + 1,1,1,2,2-pentafluoropropane (1814-88-6) + 1,1,1,3,3-Pentafluoropropane (460-73-1) + trans-1,3,3,3-tetrafluoropropene (29118-24-9) + trans-1,2-dichloro-3,3,3-trifluoropropene (25062-11-7) + (Z)-1,3,3,3-tetrafluoropropene (29118-25-0) + CF3CClFCHF2 + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0)

Conditions	Yield
With hydrogen fluoride; chlorine; 2percentCo2O3/Cr2O3, fluorided at 350 - 375℃; Product distribution / selectivity;

...Expand

1,1,1-trifluoropropylene (677-21-4) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + (Z)-1-chloro-3,3,3-trifluoro-1-propene (99728-16-2) + 2,3,3,3-tetrafluoro-propene (754-12-1) + (Z)-1,2-dichloro-3,3,3-trifluoropropene (25062-10-6) + 1,1,1,2,2-pentafluoropropane (1814-88-6) + 1,1,1,3,3-Pentafluoropropane (460-73-1) + trans-1,3,3,3-tetrafluoropropene (29118-24-9) + trans-1,2-dichloro-3,3,3-trifluoropropene (25062-11-7) + (Z)-1,3,3,3-tetrafluoropropene (29118-25-0) + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0)

Conditions	Yield
With hydrogen fluoride; chlorine; 2percentCo2O3/Cr2O3, fluorided at 300℃; Product distribution / selectivity;

...Expand

1,1,1-trifluoropropylene (677-21-4) → 1,2,2-trichloro-3,3,3-trifluoropropane (7125-83-9) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2,3-dichloro-1,1,1-trifluoropropane (338-75-0) + (Z)-1-chloro-3,3,3-trifluoro-1-propene (99728-16-2) + 2,3,3,3-tetrafluoro-propene (754-12-1) + (Z)-1,2-dichloro-3,3,3-trifluoropropene (25062-10-6) + trans-1,2-dichloro-3,3,3-trifluoropropene (25062-11-7) + 2-chloro-1,1,1,3-tetrafluoropropane (117970-90-8) + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0)

Conditions	Yield
With hydrogen fluoride; chlorine at 140℃; Gas phase;

...Expand

1,1,1-trifluoropropylene (677-21-4) → 1,2,2-trichloro-3,3,3-trifluoropropane (7125-83-9) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2,3-dichloro-1,1,1-trifluoropropane (338-75-0) + (Z)-1-chloro-3,3,3-trifluoro-1-propene (99728-16-2) + 2,3,3,3-tetrafluoro-propene (754-12-1) + 2-chloro-1,1,1,3-tetrafluoropropane (117970-90-8) + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0)

Conditions	Yield
With hydrogen fluoride; chlorine at 140℃; Gas phase;

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 1,2-dichloro-3,3,3-trifluoropropene (431-27-6)

Conditions	Yield
Stage #1: 1,1,2,3-Tetrachloropropene With hydrogen fluoride; chromium(III) oxide at 350℃; under 2311.54 Torr; for 0.00177778h; Stage #2: FeCl3/C at 180℃; under 2311.54 Torr; for 0.00244444h; Product distribution / selectivity;
With fluorinated Cr2O3 at 260℃; for 0.005h; Inert atmosphere; Gas phase;
With hydrogen fluoride at 260℃; under 760.051 Torr; for 0.005h; Catalytic behavior;

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-chloro-1,1,1,2-tetrafluoropropane (421-73-8) + 1,2-dichloro-3,3,3-trifluoropropene (431-27-6)

Conditions	Yield
Stage #1: 1,1,2,3-Tetrachloropropene With hydrogen fluoride; 4-methoxy-phenol; chromium(III) oxide at 350℃; under 1794.37 Torr; for 0.00177778h; Stage #2: FeCl3/C at 180℃; under 1794.37 Torr; for 0.00244444h; Product distribution / selectivity;

2-chloro-1,1,1,2-tetrafluoropropane (421-73-8) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2,3,3,3-tetrafluoro-propene (754-12-1)

Conditions	Yield
magnesium fluoride at 450 - 530℃; under 760.051 Torr; for 1 - 14h; Product distribution / selectivity;
iron(III) trifluoride at 350 - 385℃; under 760.051 Torr; for 1 - 2h; Product distribution / selectivity;
chromium oxide, fluorinated at 250 - 317℃; under 760.051 Torr; for 1 - 2h; Product distribution / selectivity;

1,1,2,3-Tetrachloropropene (10436-39-2) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-chloro-1,1,1,2-tetrafluoropropane (421-73-8) + 2,3,3,3-tetrafluoro-propene (754-12-1) + 1,1,1,2,2-pentafluoropropane (1814-88-6)

Conditions	Yield
With hydrogen fluoride at 100 - 120℃; under 16274.9 Torr; for 5h; Product distribution / selectivity;

2,3-dichloro-1,1,1-trifluoropropane (338-75-0) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-chloro-1,1,1,2-tetrafluoropropane (421-73-8)

Conditions	Yield
With hydrogen fluoride; activated by HF Zn/chromia catalyst at 100 - 340℃;	A 70 %Chromat. B 10 %Chromat.

1,1,1-trifluoropropylene (677-21-4) → 2-chloro-1,1,1-trifluoropropene (2730-62-3) + 1-chloro-3,3,3-trifluoropropene (2730-43-0)

Conditions	Yield
With chlorine; activated carbon catalyst at 250℃; under 760.051 Torr; Product distribution / selectivity; Inert atmosphere;
With chlorine; pyrographite at 250℃; under 760.051 Torr; Inert atmosphere;

2-chloro-1,1,1-trifluoropropene (2730-62-3) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → 1-benzyl-3-chloro-3-(trifluoromethyl)pyrrolidine

Conditions	Yield
With trifluoroacetic acid In tetrahydrofuran at 0℃; for 2h;	98%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2,5-dichlorbenzenethiol (5858-18-4) → (Z)-(2,5-dichlorophenyl)(3,3,3-trifluoroprop-1-en-1-yl)sulfane

Conditions	Yield
Stage #1: 2,5-dichlorbenzenethiol With potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: 2-chloro-1,1,1-trifluoropropene With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In isopropyl alcohol at 50℃; for 4h; stereoselective reaction;	97%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-methoxyphenylboronic acid (5720-07-0) → 1-(1,1,1-trifluoroprop-2-en-2-yl)-4-methoxybenzene (69843-08-9)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Catalytic behavior; Reagent/catalyst; Solvent; Suzuki-Miyaura Coupling; Autoclave;	95%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-hydroxy-benzaldehyde (123-08-0) → (Z)-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzaldehyde

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	93%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + [4-(benzyloxy)phenyl]boronic acid (146631-00-7) → 1-(benzyloxy)-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	91%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 3,4-(methylenedioxy)-benzeneboronic acid (94839-07-3) → 5-(1,1,1-trifluoroprop-2-en-2-yl)benzo[d][1,3]dioxole

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	89%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + m-cyanophenol (873-62-1) → (Z)-3-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzonitrile

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	89%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → 1,2-dimethoxy-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	88%

O-methylresorcine (150-19-6) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-1-methoxy-3-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	88%

4-Fluorophenol (371-41-5) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → 4-fluorophenyl 3,3,3-trifluoropropen-2-yl ether

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 70 - 90℃; for 8h;	87%

4-methylpyridine-2-thiol (18368-65-5) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-4-methyl-2-((3,3,3-trifluoroprop-1-en-1-yl)thio)pyridine

Conditions	Yield
Stage #1: 4-methylpyridine-2-thiol With potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: 2-chloro-1,1,1-trifluoropropene With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In isopropyl alcohol at 50℃; for 4h; stereoselective reaction;	86%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 3-methoxyphenylboronic acid (10365-98-7) → 1-methoxy-3-(1,1,1-trifluoroprop-2-en-2-yl)benzene (946614-13-7)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	85%

4-bromo-phenol (106-41-2) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-1-bromo-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	85%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + [3-(methoxycarbonyl)phenyl]boronic acid (99769-19-4) → methyl 3-(1,1,1-trifluoroprop-2-en-2-yl)benzoate

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	84%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 2-methoxy-phenol (90-05-1) → (Z)-1-methoxy-2-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	84%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-Iodophenol (540-38-5) → (Z)-1-iodo-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	84%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-biphenylboronic acid (5122-94-1) → 4-(3,3,3-trifluoroprop-1-en-2-yl)-1,1’-biphenyl (1601477-35-3)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	83%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + β-naphthol (135-19-3) → (Z)-2-((3,3,3-trifluoroprop-1-en-1-yl)oxy)naphthalene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	83%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + ortho-cresol (95-48-7) → (Z)-1-methyl-2-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	83%

4-Isopropylphenol (99-89-8) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-1-isopropyl-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	83%

4-Methoxybenzenethiol (696-63-9) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (4-methoxyphenyl)(3,3,3-trifluoroprop-1-en-1-yl)sulfane + (4-methoxyphenyl)(3,3,3-trifluoroprop-1-en-1-yl)sulfane

Conditions	Yield
Stage #1: 4-Methoxybenzenethiol With potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: 2-chloro-1,1,1-trifluoropropene With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In isopropyl alcohol at 50℃; for 4h; stereoselective reaction;	A 83% B 13%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-formylphenylboronic acid, (87199-17-5) → 4-(1,1,1-trifluoroprop-2-en-2-yl)benzaldehyde

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	82%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + 4-amino-phenol (123-30-8) → (Z)-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)aniline

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	82%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + (4-isopropylphenyl)boronic acid (16152-51-5) → 1-isopropyl-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-pyrrole In 1,4-dioxane; water at -100 - 100℃; for 5h; Suzuki-Miyaura Coupling; Autoclave;	81%

2-chloro-1,1,1-trifluoropropene (2730-62-3) + phenol (108-95-2) → (Z)-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene (117971-12-7)

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	81%

p-cresol (106-44-5) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-1-methyl-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	81%

4-Ethylphenol (123-07-9) + 2-chloro-1,1,1-trifluoropropene (2730-62-3) → (Z)-1-ethyl-4-((3,3,3-trifluoroprop-1-en-1-yl)oxy)benzene

Conditions	Yield
With potassium phosphate tribasic heptahydrate In N,N-dimethyl-formamide at -100 - 100℃; for 5h; Autoclave; Sealed tube;	80%

Upstream product

• 6262-51-7 pentachlorocyclopropane 
• 677-21-4 1,1,1-trifluoropropylene 
• 421-73-8 2-chloro-1,1,1,2-tetrafluoropropane 
• 10436-39-2 1,1,2,3-Tetrachloropropene 
• 338-75-0 2,3-dichloro-1,1,1-trifluoropropane 
• 113036-02-5 6-chloro-5-trifluoromethyl-1,6-diazabicyclo<3.1.0>hexane 
• 20411-85-2 2,2-dichloro-3,3,3-trifluoropropyl acetate 
• 2252-87-1 2,3-dichloro-3,3-difluoroprop-1-ene 
• 99728-16-2 (Z)-1-chloro-3,3,3-trifluoro-1-propene 
• 74-87-3 methylene chloride 
• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 23153-23-3 1,1,1,3,3-pentachloropropane 
• 2730-43-0 1-chloro-3,3,3-trifluoropropene 
• 1076-43-3 benzene-d6 

Downstream Products

• 421-73-8 2-chloro-1,1,1,2-tetrafluoropropane 
• 754-12-1 2,3,3,3-tetrafluoro-propene 
• 1814-88-6 1,1,1,2,2-pentafluoropropane 
• 420-46-2 2,2,2-trifluoroethanol 
• 99728-16-2 (Z)-1-chloro-3,3,3-trifluoro-1-propene 
• 102687-65-0 trans-1-chloro-3,3,3-trifluoropropene 
• 661-54-1 3,3,3-trifluoroprop-1-yne 
• 431-31-2 1,1,1,2,3-pentafluoropropane 
• 7126-01-4 2,2-dichloro-1,1,1-trifluoro-propane 
• 932395-39-6 (Z)-(((3,3,3-trifluoroprop-1-en-1-yl)oxy)methyl)benzene 
• 932395-40-9 ({[(1E)-3,3,3-trifluoroprop-1-en-1-yl]oxy}methyl)benzene 

Relevant articles and documents

Effects of yttrium-doping on the performance of Cr2O3 catalysts for vapor phase fluorination of 1,1,2,3-tetrachloropropene

The synthesis of 2-chloro-3,3,3-trifluoropropene (HCFC-1233xf) from 1,1,2,3-tetrachloropropene was performed over a series of Y2O 3-Cr2O3(F) catalysts and the effect of yttrium-doping on the performance of Cr2O3 catalysts was investigated. Various characterization results showed that the addition of yttrium in the Cr2O3 led to the formation of high valent Cr species in the samples, which could be consequently converted to catalytically active CrOxFy species during the pre-fluorination process. Although the Cr2O3 catalyst with or without yttrium-doping showed very high 1,1,2,3-tetrachloropropene conversion in long term reaction, the addition of yttrium in the Cr 2O3 helped to maintain the high selectivity to HCFC-1233xf, with the highest selectivity (97%) obtained on a 1 mol% yttrium-doped Cr2O3 after 100 h reaction. X-ray photon spectroscopy results on the spent Cr2O3(F) and 1Y 2O3-Cr2O3(F) catalysts indicated that the content of the active CrOxFy species declined after 70 h reaction, which was responsible for the loss of selectivity (from 97% to 88%), while it remained almost unchanged on the spent 1Y2O 3-Cr2O3(F) catalyst.

REACTION OF POLYFLUOROALKENES WITH DIPHENYLACETONITRILE CARBANION IN A TWO-PHASE SYSTEM

The carbanion of diphenylacetonitrile (DPA) generated in a catalytic two phase system reacts with polyfluoroalkenes to give addition-elimination products.Reaction of DPA with some polyfluorochloroalkenes was studied; elimination, addition-elimination and SN2 reactions were observed.

Selective dehydrofluorination of 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb) to 2-chloro-3,3,3-trifluoropropene (HFO-1233xf) using nanoscopic aluminium fluoride catalysts at mild conditions

Aluminium chlorofluoride (ACF, AlClxF3-x, x = 0.05-0.3) and high-surface aluminium fluoride (HS-AlF3) were tested as heterogeneous catalysts for the reactivity towards 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb), which is a potent greenhouse gas. Selective activation and dehydrofluorination of the C–F bond was observed, under remarkable conditions, such as mild temperatures (70 °C) and without the need for a hydrogen source as a driving force. Consecutive reactions were developed by using C6D6 as a solvent or adding Et3SiH. Thus, the production of the dehydrofluorination product 2-chloro-3,3,3-trifluoropropene (HFO-1233xf) can be coupled to a hydroarylation or hydrodefluorination reaction in one-pot procedures.

Highly Selective Dehydrochlorination of 1,1,1,2-Tetrafluoro-2-chloropropane to 2,3,3,3-Tetrafluoropropene over Alkali Metal Fluoride Modified MgO Catalysts

Gas-phase selective dehydrochlorination of 1,1,1,2-tetrafluoro-2-chloropropane (HCFC-244bb) to 2,3,3,3-tetrafluoropropene was investigated over various K and Cs halides modified MgO catalysts. The reaction proceeded in the absence of additives such as air

Process for the production of 2,3,3,3-tetrafluoropropene

A process for the production of 2,3,3,3-tetrafluoropropene including the stages: i) in a first reactor, bringing a stream A including 2-chloro-3,3,3-trifluoropropene into contact with hydrofluoric acid in the gas phase in the presence of a catalyst in order to produce a stream B including 2,3,3,3-tetrafluoropropene, HCl, HF and unreacted 2-chloro-3,3,3-trifluoropropene; and ii) in a second reactor, bringing hydrofluoric acid into contact, in the gas phase in the presence or not of a catalyst, with a stream including at least one chlorinated compound selected from the group of 1,1,1,2,3-pentachloropropane, 2,3-dichloro-1,1,1-trifluoropropane, 2,3,3,3-tetrachloropropene and 1,1,2,3-tetrachloropropene, in order to produce a stream C including 2-chloro-3,3,3-trifluoropropene, wherein the stream B obtained in stage i) feeds the second reactor used for stage ii); and wherein the electrical conductivity of the stream A provided in stage i) is less than 15 mS/cm.

Method for preparing 3, 3, 3-trifluoropropyne through gas-phase dehydrohalogenation

The invention discloses a method for preparing 3, 3, 3-trifluoropropyne through gas-phase dehydrohalogenation. The method comprises the following steps: taking 1-halogen-3, 3, 3-trifluoropropene or/and 2-halogen-3, 3, 3-trifluoropropene (halogen = F or Cl or Br or I) as a raw material, and carrying out gas-phase dehydrohalogenation reaction in the presence of a catalyst to obtain the 3, 3, 3-trifluoropropyne. The method disclosed by the invention is mainly used for producing the 3, 3, 3-trifluoropropyne in a gas-phase continuous circulation manner at a high conversion rate and high selectivity.

2-CHLORO-3,3,3-TRIFLUOROPROPENE (1233XF) COMPOSITIONS AND METHODS FOR MAKING AND USING THE COMPOSITIONS

A composition including 2-chloro-3,3,3-trifluoropropene (1233xf), one or more of 2,3-dichloro-1,1,1-trifluoropropane (243db), 1,2-dichloro-3,3,3-trifluoropropene (1223xd), 2,3-dichloro-3,3-difluoropropene (1232xf), 2,2,3-trichloro-1,1,1-trifluoro-propane (233ab), 2,3,3-trichloro-1,1,1-trifluoro-propane (233da), 3,3,3-trifluoropropyne, 1-chloro-3,3,3-trifluoropropyne, 3,3,3-trifluoro-1-propene (1243zf), 1-chloro-3,3,3-trifluoro-1-propene (1233zd), 1-chloro-2,3,3,3-tetrafluoro-1-propene (1224yd), or 2-bromo-3,3,3-trifluoropropene and optionally 1233xf oligomers are disclosed.

Method for synthesizing 2, 3, 3, 3-tetrafluoropropene and 2, 3-dichloro-1, 1, 1-trifluoropropane

The present invention relates to a novel process for the preparation of a compound 2, 3, 3, 3-tetrafluoropropene (1234yf). The compound 1234yf is the latest refrigerant, the OPD (ozone depletion potential) is zero, and the GWP (global warming potential) is zero. Therefore, the method of the present invention relates to a carbene generation pathway, the present invention relates to a process for preparing a compound 2, 3, 3, 3-tetrafluoropropene (1234yf), a compound 243db (2, 3-dichloro-1, 1, 1-trifluoropropane), and optionally a compound 2-chloro-1, 1, 1-trifluoropropene (1233xf) and a compound 243db (2, 3-dichloro-1, 1, 1-trifluoropropane) by a carbene route. The invention also relates to a method for producing the compound 2, 3, 3, 3-tetrafluoropropene (1234yf), in which compound 243db (2, 3-dichloro-1, 1, 1-trifluoropropane) is used as starting material for producing the compound 2, 3, 3, 3-tetrafluoropropene (1234yf).

Method for synthesizing 2-chloro-3, 3, 3-trifluoropropene by gas-phase fluorination

The invention relates to a method for synthesizing 2-chloro-3, 3, 3-trifluoropropene by gas-phase fluorination, which comprises the following steps: by using 1, 1, 2, 3-tetrachloropropene as a raw material, carrying out hydrogen fluoride gas-phase fluorination under the action of a pre-fluorinated composite catalyst at 240-280 DEG C under the conditions that N2 is less than or equal to 0.3 MPa tosynthesize 2-chloro-3, 3, 3, 3-trifluoropropene; wherein the composite catalyst is prepared from Cr2O3 with the mass content of 85%-98% and ZnO with the mass content of 2%-15%. According to the method, a commercialized reagent 1, 1, 2, 3-tetrachloropropene is adopted as a raw material, the conversion rate and yield of the final product polyhalogenated olefin are effectively increased under the action of the composite catalyst subjected to pre-fluorination treatment, and the method is low in cost and easy to implement.

Preparation method of 2,3,3,3-tetrafluoropropene

The invention discloses a preparation method of 2,3,3,3-tetrafluoropropene. The preparation method comprises the steps: performing telomerization on chloroethylene and CCl4 so as to produce 1,1,1,3,3-pentachloropropane, then performing dehydrochlorination so as to generate 1,1,3,3-tetrachloro-1-propylene, performing exchange of fluorine and chlorine and dehydrochlorination so as to prepare 3,3,3-trifluoro-1-chloropropene, then performing an isomerization reaction so as to obtain 3,3,3-trifluoro-2-chloropropene, performing a liquid phase fluorination reaction so as to synthesize 1,1,1,2-tetrafluoro-2-chloropropane, and finally performing dehydrochlorination so as to obtain 2,3,3,3-tetrafluoropropene. The raw materials have low price, and are easy to obtain, so that the raw material cost inthe production process of 2,3,3,3-tetrafluoropropene is reduced; an industrial chain is formed in the reaction process, and highly-economic values are provided through purification of the intermediateproducts; the reaction conditions are mild, the equipment has simple operation, the raw material conversion rate and product selectivity are high at the reaction stages, and by-products are few, so that a large industrial application prospect is achieved.