1220703-07-0Relevant articles and documents
Preparation method of Anacetrapib
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Paragraph 0041; 0047; 0048; 0049, (2017/08/28)
The invention provides a preparation method of Anacetrapib. The method includes: firstly subjecting a compound 1 to ylide reaction to obtain olefin, and then carrying out epoxidation to obtain a compound 2; then, reacting the compound 2 with a compound 3 in a solvent to prepare a compound 4, finally subjecting the compound 4 to condensation reaction to obtain a compound 5, and conducting deprotection cyclization on the compound 5 so as to obtain a compound 6 Anacetrapib. The operation method provided by the invention is simple, has low requirement for water in the reaction system, is low in process cost, and is suitable for industrial application.
PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS
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Page/Page column 11, (2010/04/27)
The compounds of Formula I are prodrugs of CETP inhibitors having a central oxazolidinone ring. The compounds cyclize by the elimination of HX to form an oxazolidinone ring after administration to a patient.