875548-97-3 Usage
Description
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol is a complex organic chemical compound characterized by a biphenyl structure with a fluorine atom, a methoxy group, an isopropyl group, and a trifluoromethyl group. The presence of a hydroxyl group attached to one of the benzene rings further distinguishes its molecular structure. 4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol is notable for its potential applications in organic chemistry and pharmaceuticals, driven by its unique structural features and the incorporation of fluorine and trifluoromethyl groups, which are known to enhance the bioavailability and metabolic stability of drug molecules.
Uses
Used in Organic Chemistry:
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol is used as a building block in organic chemistry for the synthesis of various complex molecules. Its unique structural features make it a valuable component in the creation of new organic compounds with specific properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol is used as a key intermediate in the development of novel drug molecules. The presence of fluorine and trifluoromethyl groups is particularly advantageous, as these elements can improve the pharmacological properties of drugs, including their bioavailability and metabolic stability.
Used in Medicinal Chemistry Synthesis:
4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol serves as an important candidate for medicinal chemistry synthesis. Its unique combination of functional groups allows for the design and synthesis of drug molecules with enhanced therapeutic effects and improved pharmacokinetic profiles.
Further research and studies on this compound are essential to fully explore its potential applications and to develop new methodologies for its synthesis and utilization in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 875548-97-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,5,5,4 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 875548-97:
(8*8)+(7*7)+(6*5)+(5*5)+(4*4)+(3*8)+(2*9)+(1*7)=233
233 % 10 = 3
So 875548-97-3 is a valid CAS Registry Number.
875548-97-3Relevant articles and documents
Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib
Wu, Qiuzi,Mao, Yang-Jie,Zhou, Kun,Wang, Shuang,Chen, Lei,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
, p. 4544 - 4547 (2021/05/17)
The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.
Preparation method of Anacetrapib
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, (2017/07/20)
The invention relates to a preparation method of a compound represented by the formula (I). The preparation method comprises the following steps: (1) reacting 2-chloro-5-trifluoromethyl-aniline (II) with (4-fluoro-5-isopropyl-2-methoxyphenyl)boric acid (III) to obtain 2-(4-fluoro-5-isopropyl-20methoxyphenyl)-5-trifluoromethyl-aniline (formula IV); (2) reacting the compound (formula IV) with tert-butyl nitrite, acetaldehyde, and alkalis to obtain 2-(4-fluoro-5-isopropyl-2-methoxyphenyl)-5-trifluoromethyl-benzyl alcohol (formula V); (3) reacting the compound (formula V) with a halogenation reagent, and then adding (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidine-2-one (VI) into the reaction mixture to carry out reactions so as to obtain (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-5'-isoproypyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4-methyl-1,3-oxazolidine-2-one represented by the formula (I), namely Anacetrapib.
PROCESS FOR PREPARATION OF ANACETRAPIB AND INTERMEDIATES THEREOF
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Page/Page column 24, (2014/08/06)
The present invention relates to a novel process for the preparation of anacetrapib. The present invention also relates to novel intermediate or its salt and its use in the preparation of anacetrapib.
