1152029-16-7

Basic information

• Product Name: (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol
• Synonyms: (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol
• CAS NO: 1152029-16-7
• Molecular Weight: 287.205
• Mol File: 1152029-16-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol(1152029-16-7)
• EPA Substance Registry System: (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol(1152029-16-7)

Safety Data

• Hazardous Substances Data: 1152029-16-7(Hazardous Substances Data)

Usage

General Description

The chemical (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol is a compound with a chiral center, consisting of an amino group and a hydroxyl group attached to a propan-1-ol backbone. The presence of the trifluoromethyl group in the phenyl ring gives the compound a high level of chemical stability and lipophilicity, making it useful in pharmaceutical and agrochemical applications. The chiral nature of the compound means it exists as two enantiomers, (1R,2S) and (1S,2R), with potentially different biological activities. The compound may have potential uses in the development of new drugs, agrochemicals, and other industrial applications due to its unique chemical structure and properties.

Upstream product

• 877384-16-2 benzyl (1S,2R)-2-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxy-1-methylethylcarbamate 
• 871917-79-2 benzyl {(1S)-2-[3,5-bis(trifluoromethyl)phenyl]-1-methyl-2-oxoethyl}carbamate 

Downstream Products

• 875444-06-7 (4S,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-10-3 (4R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-08-9 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-05-6 (4R,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 1620289-77-1 (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[(E)-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methylidene)amino]propan-1-ol 
• 1220703-07-0 (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol 
• 875446-37-0 anacetrapib 
• 1621254-55-4 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-3-fluorobenzoic acid 
• 1621254-61-2 methyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)benzoate 
• 1621254-62-3 ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate 
• 1621254-63-4 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)benzoic acid 
• 1621254-64-5 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoic acid 
• 1621254-59-8 methyl 4-(2-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-3-methoxypyridin-6-yl)-3-methylbenzoate 
• 1621254-60-1 4-(2-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-3-methoxypyridin-6-yl)-3-methylbenzoic acid 

Relevant articles and documents

PROCESS FOR PREPARATION OF ANACETRAPIB AND INTERMEDIATES THEREOF

The present invention relates to a novel process for the preparation of anacetrapib. The present invention also relates to novel intermediate or its salt and its use in the preparation of anacetrapib.