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| CAS No.: | 1118-89-4 |
|---|---|
| Name: | Diethyl L-glutamate hydrochloride |
| Article Data: | 11 |
| Molecular Structure: | |
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| Formula: | C9H17NO4.HCl |
| Molecular Weight: | 239.699 |
| Synonyms: | Glutamicacid, diethyl ester, hydrochloride, L- (7CI,8CI);L-Glutamic acid, diethylester, hydrochloride (9CI);Diethylglutamate hydrochloride;Glutamic acid diethyl ester hydrochloride;NSC 12960;NSC 17007;Diethyl L-glutamate hydrochloride; |
| EINECS: | 214-270-4 |
| Density: | 1.08g/cm3 |
| Melting Point: | 108-110 °C |
| Boiling Point: | 262 °C at 760 mmHg |
| Flash Point: | 86.3 °C |
| Solubility: | Soluble in water |
| Appearance: | white crystalline powder |
| Safety: | 24/25 |
| PSA: | 78.62000 |
| LogP: | 1.72240 |
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| Conditions | Yield |
|---|---|
| In ethanol at 0℃; for 4h; Reflux; | 99% |
| Conditions | Yield |
|---|---|
| With thionyl chloride | 98% |
| Stage #1: ethanol; L-glutamic acid With bis(trichloromethyl) carbonate at 70 - 75℃; for 5h; Stage #2: With hydrogenchloride at 20 - 25℃; for 0.5h; | 98% |
| Stage #1: ethanol With thionyl chloride at -10 - 10℃; for 1h; Stage #2: L-glutamic acid at 20 - 80℃; for 2h; | 77.76% |
| Conditions | Yield |
|---|---|
| at 190 - 195℃; unter vermindertem Druck, Kochen der gebildeten (S)-5-Oxo-pyrrolidin-carbonsaeure-(2) mit aethanol.HCl; |
- 64-17-5
ethanol
- 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester
- 1118-89-4
diethyl-L-glutamate hydrochloride
| Conditions | Yield |
|---|---|
| With thionyl chloride at 20℃; for 25h; Cooling with ice; |
- 1118-89-4
diethyl-L-glutamate hydrochloride
- 7498-31-9
diethyl N-(2,5-difluoro-4-nitrobenzoyl)-L-glutamate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane for 1h; | 100% |
- 1118-89-4
diethyl-L-glutamate hydrochloride
- 141412-75-1
diethyl N-(4-(N-(tert-butyloxycarbonyl)-N-prop-2-ynylamino)-2,6-difluorobenzoyl)-L-glutamate
| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane for 2h; | 100% |
- 1118-89-4
diethyl-L-glutamate hydrochloride
- 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate
| Conditions | Yield |
|---|---|
| With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 18h; | 100% |
- 38239-45-1
5-bromo-3-methyl-thiophene-2-carboxylic acid
- 1118-89-4
diethyl-L-glutamate hydrochloride
- 160743-92-0
2(S)-{[(5-bromo-3-methylthiophene-2-yl)carbonyl]amino}pentanedioic acid diethyl ester
| Conditions | Yield |
|---|---|
| With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h; | 99% |
| Conditions | Yield |
|---|---|
| In toluene | 99% |
- 1118-89-4
diethyl-L-glutamate hydrochloride
- 404586-94-3
1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline
- 130696-54-7
diethyl (tert-butoxycarbonyl)-L-glutamate
| Conditions | Yield |
|---|---|
| In diethyl ether Heating; | 98% |
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Specification
L-Glutamic acid diethyl ester hydrochloride, with the CAS register number 1118-89-4, could also be known to us as diethylester, hydrochloride,l-glutamicaci; diethyll-glutaminatehydrochloride; l-glutamic acid alpha,gamma-diester hydrochloride; l-glutamic acid alpha, gamma-diethyl ester hydrochloride; glutamic acid(oet)-oet hcl; h-glu(oet)-oet hcl ,etc. It is a white crystalline powder and if you need the safety information, you could refer to the WGK Germany 3 to get some. As for its usage, it is uaually used in the organic synthesis and pharmaceutical intermediates. The product categories of this chemical are as below: glutamic acid [glu, e], amino acids and derivatives, amino acid ethyl esters, biochemistry, amino hydrochloride, glutamic acidneurotransmitters, excitatory amino acids, neurotransmitters, peptide synthesis.
Physical properties about L-Glutamic acid diethyl ester hydrochloride are: (1)#H bond acceptors: 5; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 9; (4)Polar Surface Area: 55.84; (5)Index of Refraction: 1.452; (6)Molar Refractivity: 50.78 cm3; (7)Molar Volume: 188.1 cm3; (8)Polarizability: 20.13 ×10-24cm3; (9)Surface Tension: 37.6 dyne/cm; (10)Density: 1.08 g/cm3; (11)Flash Point: 86.3 °C; (12)Enthalpy of Vaporization: 49.97 kJ/mol; (13)Boiling Point: 262 °C at 760 mmHg; (14)Vapour Pressure: 0.0112 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/m0./s1;
(2)InChIKey=WSEQLMQNPBNMSL-FJXQXJEOSA-N;
(3)SmilesO(C(=O)[C@H](CCC(OCC)=O)N)CC.Cl
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991. |