5-HT Receptor Antagonists
5-HT receptor antagonists are pharmacological compounds that specifically block serotonin (5-hydroxytryptamine, 5-HT) receptors in the central nervous system and peripheral tissues. Serotonin receptors, classified into several subtypes (such as 5-HT1, 5-HT2, 5-HT3, etc.), mediate various physiological functions including mood regulation, gastrointestinal motility, vasoconstriction, and neurotransmission. Antagonists selectively bind to these receptors, preventing serotonin from exerting its effects. Depending on the subtype targeted, 5-HT receptor antagonists can have diverse therapeutic applications. For example, 5-HT3 receptor antagonists like ondansetron are used to prevent nausea and vomiting associated with chemotherapy, while 5-HT2 receptor antagonists such as ketanserin may be used in treating hypertension or psychiatric disorders. By blocking serotonin receptors, these antagonists modify neurotransmitter activity, providing targeted treatment options for a range of medical conditions where serotonin signaling is implicated.
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