Loxapine succinate

Base Information

• Chemical Name: Loxapine succinate
• CAS No.: 27833-64-3
• Molecular Formula: C18H18ClN3O^.C4H6O4
• Molecular Weight: 443.90
• Hs Code.: 29329990
• European Community (EC) Number: 248-682-0
• NSC Number: 759578
• UNII: X59SG0MRYU
• DSSTox Substance ID: DTXSID3045227
• Wikidata: Q27107236
• NCI Thesaurus Code: C47590
• RXCUI: 6476
• ChEMBL ID: CHEMBL1201155
• Mol file: 27833-64-3.mol

Synonyms:2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine;CL 71,563;CL-71,563;CL71,563;Cloxazepine;Hydrochloride, Loxapine;Loxapine;Loxapine Hydrochloride;Loxapine Monohydrochloride;Loxapine Succinate;Loxapinsuccinate;Loxipine Maleate;Loxipine Succinate;Loxitane;Maleate, Loxipine;Oxilapine;Succinate, Loxapine

Chemical Property of Loxapine succinate

Chemical Property:

• Appearance/Colour: White to Of-White Solid
• Melting Point: 150-152 °C
• Boiling Point: 458.6 °C at 760 mmHg
• Flash Point: 231.1 °C
• PSA: 102.67000
• LogP: 3.01860
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 445.1404486
• Heavy Atom Count: 31
• Complexity: 542

Purity/Quality:

99.0% ^*data from raw suppliers

Loxapine, Succinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.C(CC(=O)O)C(=O)O
• Recent ClinicalTrials: Fasting Study of Loxapine Succinate Capsules 25 mg and Loxitane? Capsules 25 mg
• Recent EU Clinical Trials: Tolerability and analgesic efficacy of Loxapine in patients with refractory, chemotherapy-induced neuropathic pain
• Description: Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades. Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.
• Uses: A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent choleretic Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.