77435-44-0

Basic information

• Product Name: p-acetamidobenzenesulfonyl chloride-d₄
• Synonyms: p-acetamidobenzenesulfonyl chloride-d₄
• CAS NO: 77435-44-0
• Molecular Weight: 237.644
• Mol File: 77435-44-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: p-acetamidobenzenesulfonyl chloride-d₄(CAS DataBase Reference)
• NIST Chemistry Reference: p-acetamidobenzenesulfonyl chloride-d₄(77435-44-0)
• EPA Substance Registry System: p-acetamidobenzenesulfonyl chloride-d₄(77435-44-0)

Safety Data

• Hazardous Substances Data: 77435-44-0(Hazardous Substances Data)

Upstream product

• 1076-43-3 benzene-d6 
• 15826-91-2 acetanilide-d5 
• 4165-61-1 aniline-d5 
• 4165-60-0 nitrobenzene-d5 

Downstream Products

• 1151449-42-1 p-[⁽²⁾H₄]-nitrobenzenesulfonic acid 
• 1151449-45-4 p-[⁽²⁾H₄]-nitrobenzenesulfonyl chloride 
• 1235219-21-2 p-[⁽²⁾H₄]-aminobenzene sulfonic acid 
• 1020719-82-7 sulfamethazine-d4 
• 1020719-89-4 sulfathiazole-d4 
• 1020719-86-1 sulfamethoxazole-d4 
• 1189732-52-2 C₁₃H₉⁽²⁾H₄N₃O₃S 

Relevant articles and documents

Stable isotope-labeled sulfadimidine and synthesis method thereof (by machine translation)

The invention discloses a stable isotope-labeled sulfadimidine and a synthesis method. S1: The stable isotope-labeled acetaminophthic acid chloride; S2: the stable isotope-labeled p-acetyl aminobenzyl chloride is prepared; and the stable isotope-labeled p-acetyl aminobenzyl chloride is reacted, 2 -dimethyl -4 -5 - 6 -bromopyrimidine, and the like. S3 is obtained by reacting the stable isotope-labeled acetaminophthyl chloride with chlorosulfonic acid. The formed intermediate is hydrolyzed under basic conditions to prepare a stable isotope-labeled sulfadimidine. Compared with the prior art, the method has the advantages of mild conditions, simple process, short process route, easy separation and purification of products, high yield, high chemical purity and stable isotope abundance of 99% the obtained products, and high use value, and can be used as a standard reagent for quantitatively detecting sulfadimethoxuracil; and the method has good economical. (by machine translation)

Stable isotope deuterium labeled sulfanilamide drug and preparation method thereof

The invention belongs to the technical field of chemical synthesis, and specifically relates to a stable isotope deuterium labeled sulfanilamide drug and a preparation method thereof. The preparationmethod comprises the following steps: (1) subjecting benzene-d6 (I) to a nitratlon reaction so as to prepare deuterium labeled nitrobenzene-d5 (II); (2) reducing nitro of the deuterium labeled nitrobenzene-d5 (II) so as to prepare deuterium labeled aniline-d5 (III); (3) under the conditions of anhydrous sodium acetate and glacial acetic acid, subjecting the deuterium labeled aniline-d5 (III) and acetic anhydride to a reaction so as to prepare deuterium labeled N-acetanilide-d5 (IV); (4) subjecting the deuterium labeled N-acetanilide-d5 (IV) and chlorosulfonic acid to a reaction so as to prepare deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V); and (5) allowing R to substitute chlorine of the deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V), and carrying out hydrolysis so as to prepare an isotope deuterium labeled sulfanilamide drug (VII). The preparation method provided by the invention has the advantages of simple reaction conditions, short reaction time, highconversion efficiency, strong economy, and applicability to mass synthesis.