5034-74-2

Basic information

• Product Name: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE
• Synonyms: OTAVA-BB BB7018802005;BUTTPARK 153\33-74;5-BROMO-O-VANILLIN;5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE;5-BROMO-2-HYDROXY-3-METHOXYBENZENECARBALDEHYDE;5-BROMO-3-METHOXYSALICYLALDEHYDE;5-BROMO-2-VANILLIN;Benzaldehyde, 5-bromo-2-hydroxy-3-methoxy-
• CAS NO: 5034-74-2
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.04
• EINECS: 1533716-785-6
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 5034-74-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 125-127 °C(lit.)
• Boiling Point: 277.2°Cat760mmHg
• Flash Point: 121.4°C
• Appearance: brown powder
• Density: 1.6494 (rough estimate)
• Vapor Pressure: 0.00272mmHg at 25°C
• Refractive Index: 1.4730 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.62±0.23(Predicted)
• Sensitive: Air Sensitive
• BRN: 2328601
• CAS DataBase Reference: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(5034-74-2)
• EPA Substance Registry System: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(5034-74-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 5034-74-2(Hazardous Substances Data)

Usage

Chemical Properties

brown powder

Uses

5-Bromo-2-hydroxy-3-methoxybenzaldehyde may be employed for the following syntheses:ailanthoidol, via Stille coupling6-bromo-8-methoxy-3-(methoxycarbonyl)-2H-chromen-2-onebenzimidazole-based ligand, 2-(1H-benzoimidazol-2-yl)-4-bromo-6-methoxy-phenol (HL)chromogenic reagent, 5-bromo-2-hydroxy-3-methoxybenzaldehyde-p-hydroxy benzoic hydrazone(E)-N′-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-hydroxybenzohydrazide monohydrate

InChI:InChI=1/C8H7BrO3/c1-12-7-3-6(9)2-5(4-10)8(7)11/h2-4,11H,1H3

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 1600-27-7 mercury(II) diacetate 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 90-05-1 2-methoxy-phenol 
• 7368-78-7 4-bromoguaiacol 
• 2011-06-5 2-benzyloxy-3-methoxybenzaldehyde 

Downstream Products

• 708986-35-0 2-ethoxy-5-bromo-3-methoxy-benzaldehyde 
• 139121-23-6 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (2-{[1-(5-bromo-2-hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-amide 
• 2896-67-5 2-methyl-6-methoxyphenol 
• 86232-54-4 4-bromo-2-methoxy-6-methylphenol 
• 35090-64-3 2-hydroxy-3-methoxy-5-bromobenzyl alcohol 
• 155351-68-1 2-O-benzyl-5-bromo-2-hydroxy-3-methoxybenzaldehyde 
• 7396-74-9 4-Brom-2-methoxy-5-(2-nitro-prop-1-enyl)-phenol 
• 7396-73-8 4-Brom-2-methoxy-5-(2-nitro-vinyl)-phenol 
• 7396-75-0 N,N'-bis(3-methoxy-5-bromo-salicylidene)ethylene-1,2-diamine 
• 52924-55-7 5-bromo-2,3-dihydroxybenzaldehyde 
• 101417-34-9 5-bromo-2-isopropoxy-3-methoxytoluene 
• 101417-35-0 4-isopropoxy-3-methoxy-5-methylbenzonitryle 
• 101417-37-2 4-isopropoxy-3-methoxy-5-methylbenzoyl cloride 
• 101417-36-1 4-isopropoxy-3-methoxy-5-methylbenzoic acid 

Relevant articles and documents

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A synthetic preparation method for small carbags hydrochloric acid

The present invention belongs to the field of organic chemistry, relates to a method of synthesizing berberine hydrochloride, comprising: S1: with 5-halo-o-quinoastearaldehyde and piperine ethylamine to obtain N- [2-(3,4-dimethoxyphenyl-5-yl) ethyl] -1- (5-halo-2,3-dimethoxybenzyl) methylimide; S2: to obtain 2- (3,4-diimoxyphenyl) -N- (5-bromo-2,3-dimethoxybenzyl) ethylamine; S3: to obtain 2-(3,4-dimethoxyphenyl) -N- (5-bromo-2 S4: to obtain 12-halogenated berberine derivative; S5: to obtain berberine. The present invention is free from the application of the by-product o-vanillin synthesis of o-resveratal raw material constraints, synthesis of 5- substitute o-resveratal and piperine ethylamine, and the use of the two preparation of berberine hydrochloride, with raw materials readily available, mild reaction conditions, easy to operate, high chemical yield, low cost and other advantages.