35090-64-3

Basic information

• Product Name: 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL
• Synonyms: RARECHEM AL BD 0245;5-BROMO-2-HYDROXY-3-METHOXYBENZYL ALCOHOL;4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL;4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYPHENOL
• CAS NO: 35090-64-3
• Molecular Formula: C₈H₉BrO₃
• Molecular Weight: 233.06
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 35090-64-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 299.8°Cat760mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.642g/cm³
• Vapor Pressure: 0.000656mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL(35090-64-3)
• EPA Substance Registry System: 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL(35090-64-3)

Safety Data

• Hazardous Substances Data: 35090-64-3(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(hydroxymethyl)-6-methoxybenzenol, also known as 6-Bromo-4-methoxy-2-(hydroxymethyl)phenol, is a chemical compound with the molecular formula C8H9BrO3. It is an aromatic compound that contains a bromine atom, a hydroxymethyl group, and a methoxy group attached to a benzene ring. 4-BROMO-2-(HYDROXYMETHYL)-6-METHOXYBENZENOL is commonly used in organic synthesis and pharmaceutical research. Its properties make it a versatile building block for the production of various pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, it has been shown to have antioxidant and anti-inflammatory properties, making it potentially useful in the development of new medications.

InChI:InChI=1/C8H9BrO3/c1-12-7-3-6(9)2-5(4-10)8(7)11/h2-3,10-11H,4H2,1H3

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 

Downstream Products

• 852634-93-6 2-hydroxy-3-methoxy-5-quinolin-3-yl-benzaldehyde 
• 852634-92-5 2-hydroxymethyl-6-methoxy-4-quinolin-3-yl-phenol 
• 852634-91-4 3-(3-methoxy-4-methoxymethoxy-5-methoxymethoxymethyl-phenyl)-quinoline 
• 144735-57-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane 
• 144735-56-8 5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran 
• 17375-66-5 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran 
• 530-22-3 egonol 
• 144735-55-7 5-(2-(methoxycarbonyl)trans-ethenyl)-7-methoxy-2-(3'-methoxy-4'-(benzyloxy)phenyl)benzofuran 
• 213970-70-8 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran 
• 215585-89-0 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-phenylbenzofuran 
• 164414-62-4 5-bromo-7-methoxybenzofuran 

Relevant articles and documents

Novel titanium(IV) complexes stabilized by 2-hydroxybenzyl alcohol derivatives as catalysts for UHMWPE production

A series of titanium (IV) complexes (2, 5-7) stabilized by a substituted 2-hydroxybenzyl alcohols (1, 4) – were synthesized. Structures of complexes 6-7 were determined by X-ray diffraction. Titanium atom in the tetrameric complex 6 has an octahedral envi

An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists

The synthesis of a series of 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-arylbenzofuran and 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with high subtype selectivity. Among them, compound 10e has been found to show the anti-l-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed.