213970-70-8

Basic information

• Product Name: 2-Propenoic acid, 3-[7-methoxy-2-[3-methoxy-4-(phenylmethoxy)phenyl]-5-benzofuranyl]-, ethyl ester, (2E)-
• CAS NO: 213970-70-8
• Molecular Formula: C28H26O6
• Molecular Weight: 458.511
• Mol File: 213970-70-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[7-methoxy-2-[3-methoxy-4-(phenylmethoxy)phenyl]-5-benzofuranyl]-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[7-methoxy-2-[3-methoxy-4-(phenylmethoxy)phenyl]-5-benzofuranyl]-, ethyl ester, (2E)-(213970-70-8)
• EPA Substance Registry System: 2-Propenoic acid, 3-[7-methoxy-2-[3-methoxy-4-(phenylmethoxy)phenyl]-5-benzofuranyl]-, ethyl ester, (2E)-(213970-70-8)

Safety Data

• Hazardous Substances Data: 213970-70-8(Hazardous Substances Data)

Upstream product

• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 1486-52-8 3-methoxy-4-benzyloxybenzoyl chloride 
• 140-88-5 ethyl acrylate 
• 515814-05-8 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran 
• 35090-64-3 2-hydroxy-3-methoxy-5-bromobenzyl alcohol 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 332077-65-3 2-(4-benzyloxy-3-methoxyphenyl)-7-methoxybenzo[b]furan-5-carboxaldehyde 
• 212569-07-8 2-(4-Benzyloxy-3-methoxy-phenyl)-7-hydroxy-benzofuran-5-carboxylic acid ethyl ester 
• 212569-04-5 2-(4-Benzyloxy-3-methoxy-phenyl)-4-bromo-furan 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 144735-54-6 1-ethynyl-4-(benzyloxy)-3-methoxybenzene 
• 515814-03-6 5-bromo-7-methoxy-2-bromobenzofuran 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 56897-51-9 5-bromo-7-methoxy-2-nitrobenzofuran 

Downstream Products

• 144735-57-9 2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane 
• 156398-61-7 (E)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxyprop-1-enyl)-7-methoxybenzofuran 
• 213970-71-9 2-(p-hydroxy-m-methoxyphenyl)-7-methoxy-5-(carbethoxy-1-propen-1-yl)benzo[b]furan 

Relevant articles and documents

An alternate method for the synthesis of 2-aryl/alkyl-5-bromo-7-methoxy benzofurans; application to the synthesis of Egonol, Homoegonol, and analogs via Heck reaction

We herein report the general, versatile, and convenient method for the synthesis of 2-arly/alkyl-5-bromo-7-methoxy benzofurans from easily available o-Vanillin in five steps. These benzofurans was successfully converted into biological active natural products Egonol, Homoegonol, and analogous on applying Heck reaction using ethyl/methyl acrylate in the presence of palladium catalyst.

Facile preparation of 2-arylbenzo[b]furan molecules and their anti-inflammatory effects

An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity.

A new approach to 2-aryl-7-alkoxy-benzofurans: Synthesis of ailanthoidol, a natural neolignan

A general method of synthesis of 2-aryl-7-alkoxy-benzofurans is described using a benzoannulation reaction as key step. The usefulness of this approach is shown in the new synthesis of ailanthoidol, a benzofuranoid neolignan isolated from the tree Zanthox