29490-19-5Relevant articles and documents
Efficient formation of C–S bond using heterocyclic thiones and arynes
An, Yu,Xu, Gang,Cai, Menglu,Wang, Shihui,Wang, Xiao zhong,Chen, Yingqi,Dai, Liyan
, (2020/12/23)
Phenylthio heterocyclic compounds are widely used because of their diverse biological activities and medicinal prospects. Here, a facile method was reported. An arylation of 1,3,4-oxa(thia)diazol-2-thiones reacting with arynes to build C(aryl)-S bonds in the presence of CsF had good yields and excellent selectivity. The reaction was completed in short time without using expensive reagents and catalysts. Present reaction system is an efficient procedure to process phenylthio heterocyclic compounds and reveals a sustainable method and better application prospects in future organic synthesis.
Synthesis method of 5-methyl-2-mercaptothiadiazole
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Paragraph 0020; 0023-0025; 0026; 0029-0032, (2020/12/31)
The invention discloses a synthesis method of 5-methyl-2-mercaptothiadiazole, which comprises the following steps: in an organic solvent, by using N-acetylhydrazino dithioformate as a substrate, conducting reacting under the catalysis of solid superacid to obtain 5-methyl-2-mercaptothiadiazole. The granular solid superacid adopted in the method has the characteristics of no pollution, no corrosion, easiness in reactant separation and reusability, and is an environment-friendly catalyst.
A 2-mercapto-5-methyl -1, 3, 4-thiadiazole method for the preparation of
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Paragraph 0023-0026, (2017/03/14)
The invention relates to a preparation method of 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole. The preparation method of the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole, provided by the invention, comprises the following steps of: (1) placing the weighted hydrazine hydrate and ammonium hydroxide into a reaction vessel to be uniformly mixed, dropwise adding carbon disulfide at low temperature, after the dropwise adding operation is ended, stirring and preserving the heat to obtain a water solution of diazanyl dithiocarbamate; (2) adding acetonitrile into the reaction vessel, reacting while stirring, heating, stirring, preserving heat and reflowing to obtain a water solution of 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole aluminum salt; and (3) when the reaction vessel in the step (2) is cooled to be below 40 DEG C, dropwise adding hydrochloric acid for acidifying to obtain a 2-methyl-5-sulfydryl-1, 3, 4-thiadiazole suspension, filtering and washing to obtain milk white crystal powder, namely a crude product of the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole, and then, purifying and drying the crude product to obtain white crystal powder, namely the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole. The preparation method has the characteristics of simplicity and convenience in process operation, short reaction time, low production cost and few wastes and pollutants.