79-19-6 Usage
Description
Thiosemicarbazide is an organic compound with the chemical formula NH2NHCSNH2. It is a derivative of semicarbazide, where the oxygen atom is replaced by a sulfur atom. Thiosemicarbazide is a versatile reagent and intermediate in various chemical and pharmaceutical applications.
Uses
Used in Analytical Chemistry:
Thiosemicarbazide is used as a reagent for the detection of metals, particularly in the identification and quantification of certain metal ions through the formation of colored complexes.
Used in Thin Layer Chromatography (TLC):
In TLC, thiosemicarbazide is used as a staining agent for alpha-keto acids, enabling the visualization and identification of these compounds on the TLC plate.
Used as a Reagent for Ketones:
Thiosemicarbazide is employed as a reagent for ketones, facilitating the detection and analysis of these organic compounds.
Used in Chemical Synthesis:
Thiosemicarbazide serves as a chemical intermediate in the synthesis of various organic and pharmaceutical compounds, including 1,3,4-thiadiazoles, which have potential applications in medicinal chemistry.
Used in Photography:
Thiosemicarbazide is utilized in the photography industry, where it plays a role in the development and processing of photographic films and papers.
Used in Agriculture:
Thiosemicarbazide is effective in controlling bacterial leaf blight in rice, a significant disease affecting rice crops. Its application helps in reducing the impact of the disease and improving crop yields.
Health Hazard
N-Aminothiourea is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells.
Fire Hazard
When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted.
Flammability and Explosibility
Nonflammable
Safety Profile
Poison by ingestion,
intraperitoneal, and intravenous routes.
Questionable carcinogen with experimental
tumorigenic data. Human mutation data
reported. When heated to decomposition it
emits very toxic fumes of NOx and SOx.
Potential Exposure
Thiosemicarbazide is a dithiocarbamide compound is used as an intermedialte for pharmaceuticals and herbicides; as a reagent for ketones and certain metals; in certain photography and dye operations; as a rodenticide. It is also effective for control of bacterial leaf blight of rice.
Shipping
UN2771 Thiosemicarbazide, pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Crystallise thiosemicarbazide from H2O (solubility is 20.3% w/w at 80o). The hydrochloride has m 190-191o(dec, 184o also reported). It forms salts with heavy metals. [Beilstein 3 H 195, 3 I 79, 3 II 134, 3 III 315, 3 IV 374.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.) and strong reducing agents; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May react with nitrates.
Check Digit Verification of cas no
The CAS Registry Mumber 79-19-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 9 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 79-19:
(4*7)+(3*9)+(2*1)+(1*9)=66
66 % 10 = 6
So 79-19-6 is a valid CAS Registry Number.
InChI:InChI=1/CH5N3OS/c2-1(5)4-6-3/h3H2,(H3,2,4,5)
79-19-6Relevant articles and documents
-
Pitha,Olatta
, p. 39 (1953)
-
Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma
Fouad, Marwa A.,Zaki, Mayssoune Y.,Lotfy, Raghda A.,Mahmoud, Walaa R.
, (2021/06/15)
A series of novel 3-indolinone-thiazolidinones and oxazolidinones 4a-k was synthesized via molecular hybridization approach and sequentially evaluated to explore its cytotoxic activity. The cytotoxicity screening pointed toward the N-cyclohexyl thiazolidinone derivative 4f that revealed promising renal cytotoxicity against CAKI-1 and UO-31 renal cancer cell lines with IC50 values 4.74 and 3.99 μM, respectively, which were comparable to those of sunitinib along with good safety threshold against normal renal cells. Further emphasis on compound 4f renal cytotoxicity was achieved via different enzyme assays and CAKI-1 and UO-31 cell cycle analysis. The results were supported by in silico studies to explore its physicochemical, pharmacokinetic and drug-likeness properties. Finally, compound 4f was subjected to an in vivo pharmacokinetic study through two different routes of administration showing excellent oral bioavailability. This research represents compound 4f as a promising candidate against renal cell carcinoma.
Design, synthesis, and biological evaluations of (E)-2-(1-[2-mercapto-4-methyl-1-phenyl-1H-imidazol-5-yl]ethylidene)hydrazinecarbothioamide derivatives as antimicrobial agents
Daraji, Drashti G.,Jayanthi, Sivaraman,Patel, Hitesh D.,Rajani, Dhanji P.
supporting information, (2021/12/08)
In recent year, the development of new drugs as antibacterial agents is an important resolution to overcome drug-resistant pathogens. Imidazole derivatives were synthesized using the microwave irradiation method and were characterized using spectral analysis techniques such as proton nuclear magnetic resonance, mass, and Fourier transform infrared spectroscopy. All the analogous were assessed for their in vitro antimicrobial activity and in silico; minimum inhibition concentration values of some conjugates were evaluated against extended spectrum beta-lactamases, vancomycin-resistant enterococci, and Methicillin-resistant Staphylococcus aureus strains from clinical samples. All the analogous were used as ligands in molecular docking and adsorption, distribution, metabolism, and excretion against saDHPS. Furthermore, compounds were also examined for their in vitro antituberculosis and antimalarial activity.