156-86-5 Usage
Description
Homoarginine, an L-lysine derivative, is a naturally occurring amino acid that was originally detected in significant concentrations in the seeds of many Lathyrus species. It is a white to off-white powder and has been found in small amounts in human body fluids such as urine, serum, cerebrospinal fluid, and mammalian brain. Homoarginine may be formed in mammals from lysine through a homologous urea cycle in which arginine is replaced by lysine. It is believed to serve as a nitrogen reserve in Lathyrus seeds and has been reported to inhibit the growth of various microorganisms.
Uses
1. Used in Pharmaceutical Applications:
Homoarginine is used as an inhibitor of human arginase activity, which can have potential therapeutic applications in the treatment of certain medical conditions.
2. Used in Diagnostic Applications:
Homoarginine is used as a marker for exogenous protein, helping to distinguish endogenous protein in the chyme of the intestine from food protein. This is due to the fact that homoarginine is not incorporated into endogenous secreta and free homoarginine is completely absorbed in the intestine.
3. Used in Nutritional Research:
The absorption and secretion of free homoarginine in the intestine can provide valuable insights into the bioavailability and metabolism of this amino acid, which can be useful for developing nutritional strategies and understanding its role in human health.
4. Used in Plant Biology:
The biosynthesis and function of homoarginine in plants, particularly in Lathyrus seeds, can contribute to the understanding of nitrogen storage and utilization in plants, which can have implications for agriculture and plant breeding.
5. Used in Microbiology:
The inhibitory effects of homoarginine on the growth of various microorganisms can be studied to develop potential antimicrobial agents or to understand the mechanisms of action of this amino acid in microbial growth regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 156-86-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 156-86:
(5*1)+(4*5)+(3*6)+(2*8)+(1*6)=65
65 % 10 = 5
So 156-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m1/s1
156-86-5Relevant articles and documents
Structure assignment of lucentamycin e and revision of the olefin geometries of the marine-derived lucentamycins
Cha, Jin Wook,Park, Jin-Soo,Kwon, Hak Cheol,Sim, Taebo,Nam, Sang-Jip,Fenical, William,Del Valle, Juan R.
, p. 1648 - 1651,4 (2012)
A new lucentamycin analogue, lucentamycin E (5), was isolated from the culture broth of the marine-derived actinomycete Nocardiopsis lucentensis, strain CNR-712. The absolute stereostructure of 5 was assigned by comprehensive analyses of NMR data and by application of the advanced Marfey's method. The planar structure of 5 was analogous to lucentamycins A-D, whereas the olefin geometry of the 3-methyl-4-ethylideneproline moiety was found to be E, opposite of that previously reported. Consequently, a reinvestigation of the olefin geometries of the 3-methyl-4-ethylideneproline residues of lucentamycins A-D showed that the olefin geometries of the substituted proline functionalities must be revised to (2S,3R,E)-3-methyl-4-ethylideneproline.
Novel cyclic Hexapeptide LHRH antagonists
-
, (2008/06/13)
Novel peptides of the formula: STR1 where R 1 through R 8 are various radicals derived from L- and D- amino acids; having LHRH antagonist activity; useful in reducing fertility.Pharmaceutical compositions and methods for use in reducing fertility.