85676-14-8Relevant articles and documents
Studies on analgesic oligopeptides. II. Structure-activity relationship among thirty analogs of a cyclic dipeptide, cyclo(-Tyr-Arg-)
Sasaki,Akutsu,Matsui,Suzuki,Sakurada,Sato,Kisara
, p. 4435 - 4443 (2007/10/02)
Thirty diketopiperazines were synthesized as analogs of cyclo(-Tyr-Arg-). The analgesic activities of these analogs were evaluated after intracerebral administration in mice. In the cyclo(-X-Arg-) series of analogs, cyclo[-Tyr(Et)-Arg-] showed the most po