150322-38-6Relevant articles and documents
Process improvements of prasugrel hydrochloride: An adenosine diphosphate receptor antagonist
Aalla, Sampath,Gilla, Goverdhan,Metil, Dattatray Shamrao,Anumula, Raghupathi Reddy,Vummenthala, Prabhaker Reddy,Padi, Pratap Reddy
, p. 240 - 243 (2012)
An improved process for the synthesis of prasugrel hydrochloride with an overall yield of 58%, 99.9% purity, and meeting all other quality requirements is described.
A high-purity prasugrel preparation method
-
Paragraph 0031; 0032, (2018/07/30)
A high-purity prasugrel preparation method, compared with the prior art, the invention adopts the new preparation process, by acylation and esterification, condensation, dehydrohalogenation, hydrolysis, cyclization and acetylation can be for preparing high-purity prasugrel, mild conditions, yield is higher; at the same time 1 - alkenyl - [six hydrogen pyrazoles - 1 - (α - cyclopropyl carbonyl - 2 - fluorobenzyl) - 2 - yl] - acetic acid R ester alkali is added to the catalyst so that the hydrolysis reaction can be carried through to the end, further improves the reaction yield, in addition to the 2 - acetoxy - 5 - (α - cyclopropyl carbonyl - 2 - fluorobenzyl) - 4, 5, 6, 7 - tetrahydro-thieno [3, 2 - c] pyridine has further purification, to obtain a high purity prasugrel, and the unexpected technical effects.
AN IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL INTERMEDIATES
-
Paragraph 0062; 0067; 0069-0071; 0072; 0076; 0078, (2017/12/01)
The present invention relates to an improved method for preparing 2-oxo prasugrel, 5-(andalpha;-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2,-c]pyridine (chemical formula 1), which is a major intermediate of prasugrel. More specifically, the present invention provides an improved method which is characterized by adding water as a catalyst and dividedly feeding an inorganic basic composition when 2-oxo prasugrel is synthesized through a condensation reaction between andalpha;-cyclopropylcarbonyl-2-fluorobenzylbromide represented by chemical formula 2 and 2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2,-c]pyridine hydrochloride represented by chemical formula 3.COPYRIGHT KIPO 2017