1056459-37-0 Usage
Description
5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate is a complex organic compound with a unique chemical structure. It is characterized by its tetrahydrothieno[3,2-c]pyridine core, which is substituted with a 5-chloro-1-(2-fluorophenyl)-2-oxopentyl group and an acetate group. 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate is an impurity found in Prasugrel Hydrochloride, a third-generation thienopyridine antiplatelet agent.
Uses
Used in Pharmaceutical Industry:
5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate is used as an impurity in the production of Prasugrel Hydrochloride (P701150). As a component of this antiplatelet agent, it contributes to the overall efficacy and safety profile of the drug. Prasugrel has demonstrated greater platelet inhibition and a decreased incidence of ischemic events compared to Clopidogrel, making it a valuable treatment option for patients with acute coronary syndrome.
Additionally, research into the compound's specific properties and interactions may lead to the development of new therapeutic applications, potentially expanding its use in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1056459-37-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,4,5 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1056459-37:
(9*1)+(8*0)+(7*5)+(6*6)+(5*4)+(4*5)+(3*9)+(2*3)+(1*7)=160
160 % 10 = 0
So 1056459-37-0 is a valid CAS Registry Number.
InChI:InChI=1S/C20H21ClFNO3S/c1-13(24)26-19-11-15-12-23(9-7-18(15)27-19)20(17(25)6-3-8-21)14-4-2-5-16(22)10-14/h2,4-5,10-11,20H,3,6-9,12H2,1H3
1056459-37-0Relevant articles and documents
Preparation method of prasugrel ring-opening chlorinated impurities
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Paragraph 0023-0028; 0029; 0030-0033, (2020/12/29)
The invention relates to the technical field of chemical synthesis of medicines, in particular to a preparation method of prasugrel ring-opening chlorinated impurities. The method comprises the following steps: under the action of concentrated hydrochloric acid, carrying out ring opening and chlorination on prasugrel hydrochloride (formula I) to obtain an intermediate (formula II), and reacting the intermediate II with acetic anhydride to obtain the prasugrel ring-opening chlorinated impurity (formula III). The method has the advantages of short reaction steps, cheap and easily available raw materials, simple operation and post-treatment, mild reaction conditions, good process stability, high yield and good reproducibility.
METHOD FOR PREPARING PHARMACEUTICALLY ACTIVE INGREDIENT AND INTERMEDIATES THEREOF
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, (2012/05/05)
The present invention is related to a safe and industrially applicable method for the preparation of 2-acetoxy-5-(2-fluoro-α-cyclopropyl- carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine in a quality suitable for use as pharmaceutically active ingredient wherein the concentration of the impurities of the Formula.(XXIV) or (XXIVa) is reduced.