109904-26-9 Usage
Description
5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone, with the CAS number 109904-26-9, is a chemical compound that is characterized as a beige solid. It is primarily known for its utility in the field of organic synthesis, where it serves as a valuable building block for the creation of more complex molecules and compounds.
Uses
Used in Organic Synthesis:
5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone is used as a synthetic intermediate for the development of various organic compounds. Its unique structure, which includes a thienopyridinone core with a triphenylmethyl group, allows it to be a versatile component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone is used as a key component in the synthesis of novel drug candidates. Its incorporation into drug molecules can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability, leading to the development of more effective therapeutic agents.
Used in Agrochemical Industry:
5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone is also utilized in the agrochemical industry for the synthesis of new pesticides, herbicides, and other crop protection agents. Its unique chemical structure can be exploited to design molecules with improved activity and selectivity, contributing to the development of more effective and environmentally friendly agrochemical products.
Used in Materials Science:
In the field of materials science, 5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone can be employed as a building block for the development of advanced materials with specific properties, such as optoelectronic materials, sensors, and other functional materials. Its incorporation into these materials can lead to enhanced performance and novel applications.
Check Digit Verification of cas no
The CAS Registry Mumber 109904-26-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,9,0 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 109904-26:
(8*1)+(7*0)+(6*9)+(5*9)+(4*0)+(3*4)+(2*2)+(1*6)=129
129 % 10 = 9
So 109904-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H23NOS/c28-25-18-20-19-27(17-16-24(20)29-25)26(21-10-4-1-5-11-21,22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,18,24H,16-17,19H2
109904-26-9Relevant articles and documents
Cu(OTf)2 catalyzed three component strategy for the synthesis of thienopyridine containing spirooxindoles and their cytotoxic evaluation
Parthasarathy,Praveen,Kumar, P. Senthil,Balachandran,Perumal
, p. 15818 - 15830 (2015)
Synthesis of novel spirooxindoles via a three component reaction of thienopyridines, isatins and malononitriles under copper catalysis was accomplished. This one-pot, room temperature protocol allowed the synthesis of diversely substituted spirooxindoles in good to excellent yields. Cytotoxicity towards COLO320 cells revealed that compound 5v possessing a 2,6-difluorobenzyl group (IC50 of 49.1 μM) was found to be highly potent among the screened compounds. In addition, molecular docking of compound 5v into caspase-3 receptors exhibited the largest binding energy (-10.5 kcal mol-1) compared to other compounds. The formation of a DNA ladder for compound 5v also supports the experimental results.
PROCESS FOR PREPARING A PHARMACEUTICAL COMPOUND
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Paragraph 0047-0056, (2013/03/26)
The object of the present invention is a one-pot process for preparing the 2-acetoxy-5-(2-fluoro-α-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]-pyridine (prasugrel) of the formula (I) by reacting the 5,6,7,7a-tetrahydro-4H-tieno[3,2-c]-pyridine-2-on of the formula (II) with 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-etanone of the formula (III) or with 2-chloro-1-cyclopropyl-2-(2-fluorphenyl)-etanone of the formula (IIIa) and acetylating of the formed compound of the formula (IV), wherein the reaction is carried out in the presence of an organic base with an acetylation agent without isolating the compound of the formula (IV). The coupling and acetylation are carried out in the presence of the same organic base such as triethylamine, N,N-diisopropyl-ethylamine or pyridine. At the end of the process the prasugrel of the formula (I) is purified by recrystallization from an organic solvent or a mixture of solvents.
Processes For Preparing Prasugrel And Pharmaceutically Acceptable Salts Thereof
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, (2012/08/27)
Disclosed are improved processes for preparing prasugrel compound of formula-(1), its intermediates and pharmaceutically acceptable salts.