1237261-60-7

Basic information

• Product Name: (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide
• Synonyms: (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide
• CAS NO: 1237261-60-7
• Molecular Weight: 265.783
• Mol File: 1237261-60-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide(1237261-60-7)
• EPA Substance Registry System: (1S,2R)-2-(chloromethyl)-N,N-diethyl-1- phenylcyclopropanecarboxamide(1237261-60-7)

Safety Data

• Hazardous Substances Data: 1237261-60-7(Hazardous Substances Data)

Usage

Description

(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide is a complex organic molecule that features a cyclopropane ring, a chloromethyl functional group, a diethylamine group, and a phenyl group. (1S,2R)-2-(chloromethyl)-N,N-diethyl-1-
phenylcyclopropanecarboxamide is known for its potential therapeutic applications and its use as a building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide is used as a building block for the synthesis of various pharmaceuticals due to its diverse structural features, which allow it to interact with multiple biological targets. Its presence as a versatile precursor enables the development of new drug candidates.
Used in Agrochemical Industry:
In the agrochemical industry, (1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide is utilized as a key component in the production of agrochemicals. Its cyclopropane ring structure and chloromethyl group contribute to the compound's stability and reactivity, making it suitable for use in this field.
Used for Chemical Modifications:
The chloromethyl group in (1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide makes it a valuable precursor for further chemical modifications. This allows researchers and chemists to explore its potential in creating new compounds with various applications in different industries.

Upstream product

• 109-89-7 diethylamine 
• 140-29-4 phenylacetonitrile 
• 63106-93-4 (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 172015-99-5 (1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide 

Downstream Products

• 1237261-65-2 (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide-cyclopropanecarboxamide 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 101152-94-7 (1S,2R)-milnacipran hydrochloride 
• 174848-98-7 (1S,2R)-2-(azidomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 

Relevant articles and documents

Preparation method of milnacipra hydrochloride intermediate

The invention provides a preparation method of an intermediate hydrochloride intermediate. Belong to chemical medicine preparation technical field. To the preparation method, the compound having the structure of the formula (II) is added into the methanol

Preparation method of levomilnacipran hydrochloride

The invention relates to the field of chemical medicines and organic synthesis and in particular relates to a preparation method of levomilnacipran hydrochloride. Aiming at solving the problems of anexisting method for preparing the levomilnacipran hydrochloride that the cost is relatively high or a generation process is relatively dangerous so that large-scale industrial production is limited, the preparation method is characterized by comprising the following steps: [1] enabling phenylacetonitrile and (R)-2-chloromethyl ethylene oxide to react under the action of sodium amide to obtain a compound 1; then carrying out hydrolysis cyclization on the compound 1 to obtain a compound 2; [2] enabling the compound 2 and thionyl chloride to react in alcohol, so as to obtain a compound 3; [3] enabling the compound 3 to be subjected to exchange reaction through introducing nitryl and amino, so as to obtain a compound 6; [4] reducing nitryl in the compound 6 and forming salt in situ to obtain the levomilnacipran hydrochloride. The preparation method provided by the invention is applicable to industrial production of the levomilnacipran hydrochloride.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of neurological conditions may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fibromyalgia, depression, neuropathic pain, severe pain, chronic pain, generalized pain, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, post herpetic neuralgia, diabetic neuropathy, cancer pain, fibromyalgia and lower back pain.