172015-99-5

Basic information

• Product Name: Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-
• Synonyms: Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-;(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide
• CAS NO: 172015-99-5
• Molecular Weight: 247.337
• Mol File: 172015-99-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-(172015-99-5)
• EPA Substance Registry System: Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)-(172015-99-5)

Safety Data

• Hazardous Substances Data: 172015-99-5(Hazardous Substances Data)

Usage

General Description

Cyclopropanecarboxamide, N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)- is a chemical compound that is used in the pharmaceutical industry. It is a chiral compound with a cyclopropane ring and an amide functional group. Cyclopropanecarboxamide,N,N-diethyl-2-(hydroxymethyl)-1-phenyl-,(1S,2R)- has potential therapeutic applications due to its ability to interact with biological systems. Its unique structure and properties make it valuable for research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 63106-93-4 (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 109-89-7 diethylamine 
• 34992-80-8 sodium di(ethyl)amine 
• 140-29-4 phenylacetonitrile 
• 63106-93-4 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one 
• 816-43-3 lithium diethylamide 

Downstream Products

• 1001017-62-4 (1S,2R)-2-(bromomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 
• 1237261-65-2 (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide-cyclopropanecarboxamide 
• 101152-94-7 (1S,2R)-milnacipran hydrochloride 
• 923037-67-6 C₂₂H₂₇NO₄S 
• 1237261-60-7 (1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 
• 174747-08-1 (1S,2R)-2-((S)-1-Hydroxy-ethyl)-1-phenyl-cyclopropanecarboxylic acid methyl ester 
• 172016-04-5 (1S,2R)-1-phenyl-2-<(R)-1-azidopropyl>-N,N-diethylcyclopropanecarboxamide 
• 171889-16-0 (1S,2R)-1-phenyl-2-<(S)-1-azidopropyl>-N,N-diethylcyclopropanecarboxamide 
• 172016-03-4 (1S,2R)-1-phenyl-2-<(R)-1-azidoethyl>-N,N-diethylcyclopropanecarboxamide 
• 171889-14-8 (1S,2R)-2-((S)-1-Hydroxy-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 172016-02-3 (1S,2R)-1-phenyl-2-<(R)-1-hydroxypropyl>-N,N-diethylcyclopropanecarboxamide 
• 171889-07-9 (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide 
• 172015-90-6 (1S,2R)-2-((R)-1-Amino-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide 
• 171889-18-2 (1S,2R)-1-phenyl-2-propanoyl-N,N-diethylcyclopropanecarboxamide 

Relevant articles and documents

Preparation method of milnacipra hydrochloride intermediate

The invention provides a preparation method of an intermediate hydrochloride intermediate. Belong to chemical medicine preparation technical field. To the preparation method, the compound having the structure of the formula (II) is added into the methanol

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Preparation method of levomilnacipran hydrochloride

The invention provides a preparation method of levomilnacipran hydrochloride. According to the preparation method, a mixed liquid is obtained through a mixed reaction of a compound adopting the structure shown in the formula (II) and alkali; then acid is