1206102-11-5 Usage
Uses
1. Used in Pharmaceutical Industry:
(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide is used as an intermediate in the synthesis of Dolutegravir (D528800), a potent antiviral agent. Its role in the pharmaceutical industry is crucial for the development of HIV-1 integrase strand transfer inhibitors, which are essential in the treatment of HIV/AIDS.
2. Used in Antiviral Applications:
As an antiviral agent, (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide contributes to the development of new therapies for HIV-1 infection. Its unique molecular structure allows it to inhibit the integrase enzyme, which is vital for the replication of the virus within host cells. By targeting this enzyme, the compound can help prevent the spread of the virus and improve the prognosis for patients with HIV/AIDS.
3. Used in Research and Development:
The compound's unique structure and properties make it an interesting subject for further research and development in the field of medicinal chemistry. Scientists can explore its potential applications in other areas, such as the development of new drugs for various diseases or the improvement of existing drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1206102-11-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,1,0 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1206102-11:
(9*1)+(8*2)+(7*0)+(6*6)+(5*1)+(4*0)+(3*2)+(2*1)+(1*1)=75
75 % 10 = 5
So 1206102-11-5 is a valid CAS Registry Number.
1206102-11-5Relevant articles and documents
Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis
Aoyama, Yasunori,Hakogi, Toshikazu,Fukui, Yuki,Yamada, Daisuke,Ooyama, Takao,Nishino, Yutaka,Shinomoto, Shoji,Nagai, Masahiko,Miyake, Naoki,Taoda, Yoshiyuki,Yoshida, Hiroshi,Yasukata, Tatsuro
, p. 558 - 564 (2019/04/30)
A practical and scalable synthetic method to obtain dolutegravir sodium (1) was established starting from the readily accessible material maltol (2). This synthetic method includes a scalable oxidation process of maltol and palladium-catalyzed amidation for introduction of an amide moiety, leading to a practical manufacturing method in short synthetic steps. The synthetic method demonstrated herein enables multikilogram scale manufacturing of 1 of high purity.
Intermediate of these pyridonecarboxylic carbamoylalkanoic and HIV integrase inhibitor
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Paragraph 0034, (2016/10/07)
A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
DOLUTEGRAVIR SALTS
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, (2015/02/02)
Dolutegravir potassium salt and solid state forms thereof are provided, as well as methods of making and interconverting these forms. The Dolutegravir potassium forms, and pharmaceutical compositions containing them, may be used to treat subjects in need