1206102-07-9 Usage
Description
Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate is a complex organic compound with a unique chemical structure. It is characterized by its dihydropyridine core, which is a type of chemical structure commonly found in various biologically active compounds. The molecule features a benzyloxy group, two hydroxypropyl groups, and a carboxylate group, which contribute to its specific properties and potential applications.
Uses
1. Pharmaceutical Industry:
Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate is used as an intermediate in the synthesis of Dolutegravir (D528800), a second-generation HIV-1 integrase strand transfer inhibitor. This application is due to its role in the development of a potent and effective antiretroviral drug, which is crucial in the fight against HIV/AIDS.
2. Drug Synthesis:
In the field of drug synthesis, Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate serves as a key building block for the creation of various pharmaceutical compounds. Its unique structure allows for further chemical modifications and functionalization, making it a valuable asset in the development of new drugs with potential therapeutic applications.
While the provided materials do not explicitly mention other industries or applications for Methyl 3-(benzyloxy)-1-(2,3-dihydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxylate, its chemical structure and properties suggest that it may have potential uses in other areas, such as materials science or chemical research. Further investigation and experimentation would be necessary to explore these possibilities.
Check Digit Verification of cas no
The CAS Registry Mumber 1206102-07-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,6,1,0 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1206102-07:
(9*1)+(8*2)+(7*0)+(6*6)+(5*1)+(4*0)+(3*2)+(2*0)+(1*7)=79
79 % 10 = 9
So 1206102-07-9 is a valid CAS Registry Number.
1206102-07-9Relevant articles and documents
Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis
Aoyama, Yasunori,Hakogi, Toshikazu,Fukui, Yuki,Yamada, Daisuke,Ooyama, Takao,Nishino, Yutaka,Shinomoto, Shoji,Nagai, Masahiko,Miyake, Naoki,Taoda, Yoshiyuki,Yoshida, Hiroshi,Yasukata, Tatsuro
, p. 558 - 564 (2019/04/30)
A practical and scalable synthetic method to obtain dolutegravir sodium (1) was established starting from the readily accessible material maltol (2). This synthetic method includes a scalable oxidation process of maltol and palladium-catalyzed amidation for introduction of an amide moiety, leading to a practical manufacturing method in short synthetic steps. The synthetic method demonstrated herein enables multikilogram scale manufacturing of 1 of high purity.
Improved method for synthesizing dolutegravir
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Paragraph 0032; 0036, (2019/03/30)
The invention relates to an improved method for synthesizing dolutegravir and belongs to the field of medicinal chemistry. The method takes maltol (compound 1) as a raw material, and a target is synthesized by the following route. The process raw material is cheap and easy to obtain, a reaction solvent can be recycled, the post-treatment operation is simple, the yield and the purity are high, especially the carbamoylation and debenzylation reaction are carried out in one step, the synthesis route is simplified, the cost is reduced, and the large-scale industrial production is facilitated.
Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
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, (2016/02/12)
A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.
