1229006-25-0

Basic information

• Product Name: Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate
• Synonyms: Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate;Methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate
• CAS NO: 1229006-25-0
• Molecular Formula: C₂₄H₂₀F₂N₂O₆
• Molecular Weight: 470.4222064
• Mol File: 1229006-25-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 689.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• PKA: 10.66±0.40(Predicted)
• CAS DataBase Reference: Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate(1229006-25-0)
• EPA Substance Registry System: Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate(1229006-25-0)

Safety Data

• Hazardous Substances Data: 1229006-25-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "Methyl 5-[[[(2,4-difluorophenyl)methyl]amino]carbonyl]-1-(2-oxoethyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate" is a complex molecule with multiple functional groups. It is a pyridine derivative with a methyl ester group and a carbonyl group. The compound also contains a difluorophenylmethylamino group and a phenylmethyloxy group. It is a white crystalline solid with potential applications in pharmaceuticals and organic synthesis. Its precise chemical properties and potential uses would need to be further investigated and characterized.

Upstream product

• 1229006-21-6 1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 
• 1357289-08-7 2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate 
• 82961-76-0 4-benzyloxy-3-oxobutyric acid methyl ester 
• 100-51-6 benzyl alcohol 
• 1246616-65-8 methyl 4-benzyloxy-2-((dimethylamino)methylene)acetoacetate 
• 1246616-66-9 dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 
• 61049-69-2 3-O-benzylmaltol 
• 1229006-20-5 1-[2,2-bis(methyloxy)ethyl]-5-bromo-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 
• 1229006-19-2 1-[2,2-bis(methyloxy)ethyl]-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 
• 1229006-18-1 1-[2,2-bis(methyloxy)ethyl]-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridine carboxylic acid 
• 100-39-0 benzyl bromide 
• 500371-01-7 3-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde 
• 118-71-8 Maltol 
• 119736-16-2 3-(benzyloxy)-1-((tert-butoxycarbonyl)amino)-4-oxo-1,4-dihydropyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 1309561-98-5 (3R,11aS)-N-[(2,4-difluorophenyl)methyl]-3-methyl-5,7-dioxo-6-[(phenylmethyl)oxy]-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 
• 1309561-99-6 (4aR,13aS)-N-[(2,4-difluorophenyl)methyl]-9,11-dioxo-10-[(phenylmethyl)oxy]-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1',2':3,4]imidazo[1,2-d]pyrazine-8-carboxamide 
• 1206102-11-5 (4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide 
• 1357289-24-7 C₂₈H₂₉F₂N₃O₆ 
• 1357289-26-9 C₂₇H₂₇F₂N₃O₆ 
• 1357289-27-0 C₂₇H₂₅F₂N₃O₅ 
• 1051375-16-6 dolutegravir 
• 1051375-19-9 (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino-[2,1-b][1,3]oxazine-9-carboxamide sodium salt 
• 1206103-45-8 (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-3-methyl-5,7-dioxo-6-[(phenylmethyl)oxy]-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 
• 1446828-13-2 C₂₇H₂₅F₂N₃O₅ 
• 1051375-10-0 (3R,11aS)-N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 
• 1051375-10-0 (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide 

Relevant articles and documents

Intermediate of these pyridonecarboxylic carbamoylalkanoic and HIV integrase inhibitor

A synthesis approach providing an early ring attachment via a bromination to compound I-I yielding compound II-II: whereby a final product such as AA: can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.

PROCESS FOR THE PREPARATION OF INTERMEDIATE OF DOLUTEGRAVIR

The present invention provides a novel processes for preparation of methyl 3- (benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-l-(2-oxoethyl)-l,4-dihydropyiridine-2- carboxylate using novel intermediates.

PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS

Processes are provided which create an aldehyde methylene, or hydrated or hemiacetal methylene attached to a heteroatom of a 6 membered ring without going through an olefinic group and without the necessity of using an osmium reagent. In particular, a comopound of formula (I) can be produced from (II) and avoid the use of an allyl amine: (formulae I and II) where R, P 1 P3, R3 and Rx are as described herein.