119062-05-4 Usage
Description
Fmoc-L-aspartic acid, also known as N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid, is a synthetic derivative of the naturally occurring amino acid L-aspartic acid. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group attached to the amino group, which is crucial for its applications in peptide synthesis. Fmoc-L-aspartic acid is a white solid with specific chemical properties that make it a valuable component in various industries.
Uses
Used in Pharmaceutical Industry:
Fmoc-L-aspartic acid is used as a building block for the synthesis of peptides and proteins. Its Fmoc protecting group allows for the stepwise assembly of peptide chains, facilitating the controlled and efficient synthesis of complex biological molecules. This is particularly important in the development of new drugs and therapeutic agents.
Used in Biochemical Research:
In biochemical research, Fmoc-L-aspartic acid serves as a reagent for the study of protein structure and function. Its ability to be incorporated into peptides and proteins allows researchers to investigate the role of specific amino acid sequences in biological processes and to develop a deeper understanding of molecular interactions.
Used in Food Industry:
Fmoc-L-aspartic acid is used as a flavor enhancer in the food industry. It can be used to improve the taste of various food products by mimicking the natural umami taste, which is associated with the savory flavor found in certain foods such as meat, cheese, and tomatoes.
Used in Cosmetics Industry:
In the cosmetics industry, Fmoc-L-aspartic acid is used as an ingredient in skincare products. Its ability to bind with other molecules can help improve the texture and feel of cosmetic formulations, providing a smoother and more pleasant application experience for consumers.
Used in Biomaterials and Tissue Engineering:
Fmoc-L-aspartic acid is used in the development of biomaterials and tissue engineering applications. Its ability to form stable complexes with other molecules can be leveraged to create materials with specific properties, such as controlled degradation rates or enhanced biocompatibility, which are essential for medical implants and tissue scaffolds.
Check Digit Verification of cas no
The CAS Registry Mumber 119062-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,0,6 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 119062-05:
(8*1)+(7*1)+(6*9)+(5*0)+(4*6)+(3*2)+(2*0)+(1*5)=104
104 % 10 = 4
So 119062-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H17NO6/c21-17(22)9-16(18(23)24)20-19(25)26-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16H,9-10H2,(H,20,25)(H,21,22)(H,23,24)/t16-/m0/s1
119062-05-4Relevant articles and documents
Profiling primary protease specificity by peptide synthesis on a solid support
Doeze, Ron H. P.,Maltman, Beatrice A.,Egan, Claire L.,Ulijn, Rein V.,Flitsch, Sabine L.
, p. 3138 - 3141 (2004)
Reverse screening: A greatly simplified primary screening of protease specificity has been achieved by monitoring the fluorescence during the protease-catalyzed coupling of amino acids instead of peptide hydrolysis on a solid support (see picture, AA = amino acid). This approach paves the way for flexible, rapid, high-throughput identification and characterization of proteases without the need for expensively labeled peptide arrays.
A new polymer-supported reagent for the Fmoc-protection of amino acids
Chinchilla, Rafael,Dodsworth, David,Nájera, Carmen,Soriano, José
, p. 7579 - 7581 (2001)
A new polymer-supported Fmoc-OSu (Fmoc-P-OSu) has been prepared from polymer-bound N-hydroxysuccinimide (P-HOSu), and used as a solid-supported reagent for the Fmoc-protection of amino groups. The residual P-HOSu generated after the protection reaction can be separated by simple filtration and reused.
Ethyl substituted coumarin-4-yl derivatives as photoremovable protecting groups for amino acids with improved stability for SPPS
Weis, Simone,Shafiq, Zahid,Gropeanu, Radu A.,Del Campo, Aránzazu
scheme or table, p. 52 - 57 (2012/09/07)
The synthesis, photochemical properties and chemical stability of 7-(N,N-diethylamino-coumarin-4-yl)-1-ethyl (DEACE) photoremovable protecting group for carboxylic acids are presented. We demonstrate that the ethyl substituent of DEACE improves the hydrolytic stability of the protected ester in basic conditions used in solid phase peptide synthesis (SPPS) and retains the good photochemical properties of the coumarin-4-yl methyl derivatives. DEACE allows the preparation of peptides with protected carboxylic side groups with high yield via SPPS.
A microwave-assisted synthesis of (S)-N-protected homoserine γ-lactones from l-aspartic acid
Singh, Suneel P.,Michaelides, Alex,Merrill, A. Rod,Schwan, Adrian L.
experimental part, p. 6825 - 6831 (2011/10/08)
A three-pot preparation of (S)-N-protected homoserine γ-lactones is presented. Conversion of N-protected l-aspartic acid to an oxazolidinone is followed by selective reduction/acid-catalyzed cyclization to deliver the lactones. Microwave irradiation proved valuable for improving the latter reaction steps in some cases.
