105832-38-0 Usage
Description
TSTU, also known as N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium tetrafluoroborate, is a chemical compound commonly used in the conversion of carboxylic acids into the corresponding N-hydroxysuccinimidyl (NHS) esters. It is a white crystalline substance with significant applications in various fields due to its peptide coupling reagent properties.
Uses
Used in Pharmaceutical Industry:
TSTU is used as a peptide coupling reagent for the clean in-situ formation of N-succinimidyl active esters. This application is particularly important in the synthesis of peptides and other biomolecules, as it facilitates the formation of amide bonds between carboxylic acid and amine groups, leading to the creation of desired peptide structures.
Used in Chemical Synthesis:
TSTU is used as a reagent in chemical synthesis, specifically for converting carboxylates to N-succinimidyl active esters. This conversion is crucial in the formation of various chemical compounds and contributes to the development of new materials and products in the chemical industry.
Used in Research and Development:
TSTU is utilized as a peptide coupling reagent in solvent systems, which is essential for research and development in the field of biochemistry and molecular biology. This application aids in the study of protein structure, function, and interactions, as well as the development of new drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 105832-38-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,8,3 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 105832-38:
(8*1)+(7*0)+(6*5)+(5*8)+(4*3)+(3*2)+(2*3)+(1*8)=110
110 % 10 = 0
So 105832-38-0 is a valid CAS Registry Number.
105832-38-0Relevant articles and documents
Highly efficient one-pot assembly of peptides by double chemoselective coupling
Sampaio-Dias, Ivo E.,Sousa, Carlos A. D.,Silva-Reis, Sara C.,Ribeiro, Sara,García-Mera, Xerardo,Rodríguez-Borges, José E.
supporting information, p. 7533 - 7542 (2017/09/27)
This study describes a methodological advancement in solution-phase peptide synthesis via the development of a convenient and operational protocol to synthesize oligopeptides in a one-pot three-step cascade method, in which two peptide bonds are introduced chemoselectively. Tri- to hexapeptides were obtained in high global yields (80-95%) with virtually no epimerization as determined via HPLC. The methodology described herein represents a faster, easier and milder approach to the synthesis of peptides, and it operates at equimolar amounts. This protocol comprises the formation of secondary and tertiary amides and is compatible with Z, Boc and Fmoc N-protecting groups as well as the use of d/l and non-proteinogenic amino acids.
