122030-76-6

Basic information

• Product Name: 4-acetylbenzoic acid 2,5-dioxopyrrolidin-1-yl ester
• Synonyms: 4-acetylbenzoic acid 2,5-dioxopyrrolidin-1-yl ester
• CAS NO: 122030-76-6
• Molecular Weight: 261.234
• Mol File: 122030-76-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-acetylbenzoic acid 2,5-dioxopyrrolidin-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetylbenzoic acid 2,5-dioxopyrrolidin-1-yl ester(122030-76-6)
• EPA Substance Registry System: 4-acetylbenzoic acid 2,5-dioxopyrrolidin-1-yl ester(122030-76-6)

Safety Data

• Hazardous Substances Data: 122030-76-6(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 201230-82-2 carbon monoxide 
• 99-90-1 para-bromoacetophenone 
• 3457-45-2 p-formylacetophenone 
• 586-89-0 4-acetyl-benzoic acid 
• 105832-38-0 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 
• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 13329-40-3 4-Iodoacetophenone 

Downstream Products

• 850079-64-0 4-acetyl-N-((5S)-5-amino-5-carbamoylpentyl)benzamide trifluoroacetic acid salt 
• 946570-07-6 N-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2-(4-acetylbenzoylamino)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)-ethoxy)ethoxy)ethoxy)ethoxy)ethyl)-3-(prop-2-ynyloxy)benzoic amide 

Relevant articles and documents

A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

A copper-catalysed oxidative amidation of aldehydes via N-hydroxysuccinimide ester formation is reported. The methodology employed to prepare amides directly from aldehydes has a very wide scope, is high yielding, and does not need dry conditions. This cross-coupling reaction appears to be simple and makes use of cheap, abundant and easily available reagents.

DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE

The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.

General method for the preparation of active esters by palladium-catalyzed alkoxycarbonylation of aryl bromides

A useful method was developed for the synthesis of active esters by palladium-catalyzed alkoxycarbonylation of (hetero)aromatic bromides. The protocol was general for a range of oxygen nucleophiles including N-hydroxysuccinimide (NHS), pentafluorophenol (PFP), hexafluoroisopropyl alcohol (HFP), 4-nitrophenol, and N-hydroxyphthalimide. A high functional group tolerance was displayed, and several active esters were prepared with good to excellent isolated yields. The protocol was extended to access an important synthetic precursor to the HIV-protease inhibitor, saquinavir, by formation of an NHS ester followed by acyl substitution.