Technology Process of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid
There total 10 articles about 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
water; acetonitrile;
at 76 ℃;
for 6h;
Reagent/catalyst;
Solvent;
Temperature;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / 2 h / 0 - 20 °C
2: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere
3: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C
4: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C
5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
With
pyridine; hydrogenchloride; sodium azide; water; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2014.07.011
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium acetate; N-Bromosuccinimide / tetrahydrofuran; water / 2 h / 20 °C
1.2: 20 - 80 °C
2.1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux
3.1: 0.5 h / 100 °C
4.1: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7
5.1: pyridine / 2 h / 0 - 20 °C
6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere
7.1: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C
8.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C
9.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
With
pyridine; hydrogenchloride; N-Bromosuccinimide; sodium azide; water; sodium acetate; N-ethyl-N,N-diisopropylamine; Sucrose;
In
tetrahydrofuran; aq. phosphate buffer; n-heptane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2014.07.011
