Pramipexole

Base Information

• Chemical Name: Pramipexole
• CAS No.: 191217-81-9
• Molecular Formula: C₁₀H₁₇N₃S*2ClH*H₂O
• Molecular Weight: 302.268
• Hs Code.: 2934200000
• Mol file: 191217-81-9.mol

Synonyms:2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)- (9CI);Mirapex;Pramipexole dihydrochloride monohydrate;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-, hydrochloride, hydrate (1:2:1), (6S)-;Pramipexole;

Chemical Property of Pramipexole

Chemical Property:

• Appearance/Colour: gray white crystalline powder
• Vapor Pressure: 9.93E-11mmHg at 25°C
• Melting Point: 290 °C(dec.)
• Boiling Point: 378 °C at 760 mmHg
• Flash Point: 182.4 °C
• PSA: 88.41000
• LogP: 4.09400
• Storage Temp.: 2-8°C
• Solubility.: Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

Pramipexole dihydrochloride monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Antidepressant; antiparkinsonian; antischizophrenic; dopamine agonist.
• Clinical Use: Parkinson’s disease Symptomatic treatment of restless legs
• Drug interactions: Potentially hazardous interactions with other drugs Avoid concomitant use with antipsychotics.

Technology Process of Pramipexole

There total 4 articles about Pramipexole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

(S)?2?amino?6?propionamido?4,5,6,7?tetrahydrobenzothiazole (106006-84-2) → pramipexole dihydrochloride monohydrate (191217-81-9,908244-04-2)

Guidance literature:

(S)?2?amino?6?propionamido?4,5,6,7?tetrahydrobenzothiazole; With sodium tetrahydroborate; sulfuric acid; In tetrahydrofuran; at 10 ℃; for 2h;

With hydrogenchloride; Reagent/catalyst;

Reference yield: 90.0%

pramipexole (104632-26-0) → pramipexole dihydrochloride monohydrate (191217-81-9,908244-04-2)

Guidance literature:

With hydrogenchloride; water; In isopropyl alcohol; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield: 67.0%

2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid (943319-02-6) → pramipexole dihydrochloride monohydrate (191217-81-9,908244-04-2)

Guidance literature:

With hydrogenchloride; water; In isopropyl alcohol; at 5 - 20 ℃; for 12.5h; Product distribution / selectivity;

upstream raw materials:

pramipexole

2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid

pramipexole dihydrochloride

(S)?2?amino?6?propionamido?4,5,6,7?tetrahydrobenzothiazole

Refernces

• 1、 Zivec, Matej,Anzic, Borut,Gobec, Stanislav. "A novel scalable synthesis of pramipexole". experimental part. p. 1125 - 1129. Retrieved 2011/04/12.
• 2、 -. "PROCESS FOR THE PREPARATION OF PRAMIPEXOLE BASE AND/OR ITS SALTS". Page/Page column 7-8. . Retrieved 2008/06/13.