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| CAS No.: | 3184-13-2 |
|---|---|
| Name: | L(+)-Ornithine hydrochloride |
| Molecular Structure: | |
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|
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| Formula: | C5H13ClN2O2 |
| Molecular Weight: | 168.623 |
| Synonyms: | L-Ornithine,monohydrochloride (9CI);Ornithine, monohydrochloride, L- (8CI);L-Ornithine hydrochloride;Ornithine hydrochloride;Ornithine monohydrochloride;L-Ornithine HCL;H-Orn-OH·HCl;L-Ornithine,hydrochloride (1:1); |
| EINECS: | 221-678-6 |
| Density: | 1.57 g/cm3 |
| Melting Point: | 245 °C |
| Boiling Point: | 308.7oC at 760 mmHg |
| Flash Point: | 140.5oC |
| Solubility: | H2O: 100 mg/mL |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 24/25-37/39-26 |
| PSA: | 89.34000 |
| LogP: | 1.33980 |
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| Conditions | Yield |
|---|---|
| With dipotassium hydrogenphosphate; phosphoric acid; water at 25 - 37.1℃; Thermodynamic data; ΔH; arginase (EC 3.5.3.1); var. pH and ionic strength; |
- 26302-89-6
L-ornithine tert-butyl ester
- 3184-13-2
L-ornithine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | 2.7 mmol |
- 271601-28-6
1,1-dimethylethyl 4-cyano-(2S)-[(diphenylmethylene)amino]butanoate
- 3184-13-2
L-ornithine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 96 percent / aq. citric acid / tetrahydrofuran / 3 h 2: H2 / platinum oxide / acetic acid / 16 h 3: 2.7 mmol / aq. HCl / Heating View Scheme |
- 824956-17-4
tert-butyl 2-amino-4-cyanobutanoate
- 3184-13-2
L-ornithine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: H2 / platinum oxide / acetic acid / 16 h 2: 2.7 mmol / aq. HCl / Heating View Scheme |
| Conditions | Yield |
|---|---|
| With thionyl chloride at 0℃; Reflux; | 100% |
| Conditions | Yield |
|---|---|
| Stage #1: L-ornithine hydrochloride With calcium hydroxide In water for 0.5h; Stage #2: phenylacetic acid In water Product distribution / selectivity; | 100% |
| Stage #1: L-ornithine hydrochloride With acetic acid In water at 25 - 40℃; for 72h; Stage #2: phenylacetic acid In water; isopropyl alcohol |
- 24424-99-5
di-tert-butyl dicarbonate
- 3184-13-2
L-ornithine hydrochloride
- 1154761-18-8
N,N-di-boc-ornithine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran; water for 12h; | 99% |
- 3184-13-2
L-ornithine hydrochloride
- 42538-31-8
(3S)-3-aminopiperidin-2-one hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: L-ornithine hydrochloride With chloro-trimethyl-silane In methanol at 20℃; under 760.051 Torr; for 12h; Stage #2: With sodium ethanolate In methanol; ethanol at 0 - 20℃; under 760.051 Torr; for 0.583333h; enantioselective reaction; | 97% |
| Multi-step reaction with 2 steps 1: SOCl2 / -15 - 20 °C 2: 2.25 mg / Et3N / acetonitrile / 4 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 2: 1.) sodium methylate, 2.) hydrochloric acid View Scheme | |
| Multi-step reaction with 2 steps 1: thionyl chloride / 3 h / 0 - 55 °C / Large scale 2: sodium carbonate / water / 12 h / 5 - 20 °C / Large scale View Scheme |
- 3184-13-2
L-ornithine hydrochloride
| Conditions | Yield |
|---|---|
| In methanol | 97% |
| In methanol | 97% |
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
- 3184-13-2
L-ornithine hydrochloride
- 147071-84-9
(S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminopentanoic acid
| Conditions | Yield |
|---|---|
| Stage #1: L-ornithine hydrochloride With copper diacetate; sodium carbonate for 0.75h; Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In 1,4-dioxane; water for 0.75h; Further stages.; | 96% |
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Consensus Reports
- Reported in EPA TSCA Inventory.
Specification
1. Introduction of L(+)-Ornithine hydrochloride
L(+)-Ornithine hydrochloride (3184-13-2), with the IUPAC name of 2,5-diaminopentanoic acid hydrochloride, is one kind of white crystalline powder. And it belongs to the product categories which include Amino Acid Derivatives; Ornithine [Org]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids; Biochemistry; non-Proteinorganic Amino Acids; L-Amino Acids; Amino Hydrochloride. Besides, it is , which should be stored in closed, cool and dry place.
2. Chemical properties of L(+)-Ornithine hydrochloride
The other characteristics of L(+)-Ornithine hydrochloride can be summarized as: (1)EINECS: 221-678-6; (2)ACD/LogP: -0.96; (3)# of Rule of 5 Violations: 1; (4)ACD/LogD (pH 5.5): -4.46; (5)ACD/LogD (pH 7.4): -4.36; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 4; (11)#H bond donors: 5; (12)#Freely Rotating Bonds: 6; (13)Polar Surface Area: 32.78 Å2; (14)Density: 1.57 g/cm3; (15)Flash Point: 140.5 °C; (16)Melting point: 245 °C; (17)alpha: 24 °(c=4, 6N HCl); (18)Solubility: H2O: 100 mg/mL; (19)Enthalpy of Vaporization: 60.42 kJ/mol; (20)Boiling Point: 308.7 °C at 760 mmHg; (21)Vapour Pressure: 0.00015 mmHg at 25 °C.
3. Preparation of L-Ornithine hydrochloride
L(+)-Ornithine hydrochloride can be prepared by the reaction of phthalimido-(3-phthalimido-propyl)-malonic acid diethyl ester with phthalic acid.
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This reaction needs cc.HCl, HOAc and H2O at temperature of 100 °C. The yield is 62 %.
4. Uses of L-Ornithine hydrochloride
L-Ornithine hydrochloride is used as antidote and liver function accelerating agent to treat cirrhosis. It is also used to recover disease and to invigorate health effectively. Additionally, it can be used to produce 3-amino-piperidin-2-one.
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This reaction needs Al2O3 and toluene by heating for 3 hours. The yield is 79 %.
5. Safety information of L(+)-Ornithine hydrochloride
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-37/39-26
WGK Germany 3
RTECS RM2985000
F 3-10
HS Code 29224995
When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable gloves and eye/face protection to avoid contact with skin and eyes.
6. Structure Descriptors of L(+)-Ornithine hydrochloride
People can use the following data to convert to the molecule structure.
(1)SMILES: Cl.O=C(O)C(N)CCCN
(2)InChI: InChI=1/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H
(3)InChIKey: GGTYBZJRPHEQDG-UHFFFAOYAF
7. Toxicity of L(+)-Ornithine hydrochloride
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | oral | 10gm/kg (10000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmaceutical Sciences. Vol. 62, Pg. 49, 1973. |
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