lower price Dacinostat（LAQ-824）(404951-53-7) supply CAS NO.404951-53-7

Min.Order Quantity:: 1 Gram

Purity:: 99

Port:: shenzhen

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Product Details

Keywords

Dacinostat
404951-53-7
LAQ-824

Quick Details

ProName: lower price Dacinostat（LAQ-824）(404951...
CasNo: 404951-53-7
Molecular Formula: C22H25N3O3
Appearance: white powder
Application: used for research
DeliveryTime: Within 3 days after receive payment
PackAge: Sealed aluminum foil package
Port: shenzhen
ProductionCapacity: Metric Ton/Day
Purity: 99
Storage: cool and dry place
Transportation: By courier/ By air
LimitNum: 1 Gram
Related Substances: Not available
Residue on Ignition: Not available
Heavy Metal: Not available
Valid Period: Not available

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Details

laq824 activates the expression of the gene encoding the p21 cell cycle inhibitor by activating the p21 promoter with 50% of the maximal promoter activation (ac50) of 0.30 μm. laq824 inhibits the cell growth of both h1299, a non-small cell lung carcinoma line, and hct116, a colon cancer cell line with ic50 of 0.15 μm and 0.01 μm, respectively, and the antiproliferative effect of laq824 is selective toward the tumor cell lines while inducing only growth arrest in normal fibroblasts. furthermore, laq824 induces a dose-dependent increase of p21 protein in a549 cells and an increase in the hypophosphorylated state of the rb tumor suppressor.a recent study shows that laq824 induces chromatin changes at the level of the il-10 gene promoter that lead to enhanced recruitment of the transcriptional repressors hdac11 and pu.1 and inhibits il-10 production in balb/c murine macrophages.

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