Products Categories
Basic Information
| CAS No.: | 571188-59-5 |
|---|---|
| Name: | OTAVA-BB 1207229 |
| Article Data: | 76 |
| Molecular Structure: | |
|
|
|
| Formula: | C14H22N4O2 |
| Molecular Weight: | 278.354 |
| Synonyms: | tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; |
| Density: | 1.182g/cm3 |
| Melting Point: | 130-132℃ |
| Boiling Point: | 454.066oC at 760 mmHg |
| Flash Point: | 228.411oC |
| PSA: | 71.69000 |
| LogP: | 2.30500 |
Related products
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
Synthetic route
- 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethanol; water for 2h; | 100% |
| With palladium on activated charcoal; hydrogen In ethanol for 3h; | 100% |
| With palladium 10% on activated carbon; hydrogen In methanol at 25℃; under 2250.23 Torr; for 4h; Autoclave; | 99.1% |
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| With 5%-palladium/activated carbon; hydrogen; ammonium chloride In methanol at 40 - 45℃; under 1500.15 - 2250.23 Torr; Temperature; Reagent/catalyst; Pressure; Solvent; Autoclave; | 95.3% |
- 504-29-0
2-aminopyridine
- 57260-71-6
1-t-Butoxycarbonylpiperazine
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In 1,2-dichloro-ethane for 10h; Reagent/catalyst; Irradiation; | 95% |
- 24424-99-5
di-tert-butyl dicarbonate
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| In methanol; water at 20℃; Solvent; Inert atmosphere; | 94% |
- 20511-12-0
2-amino-5-iodopyridine
- 57260-71-6
1-t-Butoxycarbonylpiperazine
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| With potassium phosphate; copper(l) iodide; ethylene glycol In isopropyl alcohol at 110℃; for 10h; Ullmann Condensation; Sealed tube; | 85% |
- 775288-71-6
1-(6-nitropyridin-3-yl)piperazine
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 190.93 g / aq. NaHCO3 / tetrahydrofuran / 3 h 2: 83 percent / H2 / Raney Nickel / methanol / 5 h / 2585.74 Torr View Scheme | |
| Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 50 °C 2: 10% palladium on activated carbon; hydrogen / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; tetrahydrofuran / 3 h / 20 °C 2: hydrogen / water; methanol / 5 h / 2585.81 Torr View Scheme | |
| Multi-step reaction with 2 steps 1: dmap; triethylamine / dichloromethane / 8 h / 20 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C View Scheme |
- 39856-50-3
5-bromo2-nitropyridine
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: tetra-n-butylammonium iodide; K2CO3 / dimethylsulfoxide / 80 - 100 °C 2: 190.93 g / aq. NaHCO3 / tetrahydrofuran / 3 h 3: 83 percent / H2 / Raney Nickel / methanol / 5 h / 2585.74 Torr View Scheme | |
| Multi-step reaction with 3 steps 1: tetra-(n-butyl)ammonium iodide; potassium carbonate / dimethyl sulfoxide / 80 °C 2: triethylamine / tetrahydrofuran / 50 °C 3: 10% palladium on activated carbon; hydrogen / methanol View Scheme | |
| Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 65 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / Inert atmosphere View Scheme |
- 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| In methanol; n-heptane; water; hydrogen |
- 57260-71-6
1-t-Butoxycarbonylpiperazine
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 65 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / Inert atmosphere View Scheme | |
| Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 65 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 1-methyl-pyrrolidin-2-one / 3 h / 120 °C 2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h View Scheme |
- 24424-99-5
di-tert-butyl dicarbonate
- 571188-59-5
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: potassium carbonate / water; tetrahydrofuran / 1.5 h / 5 - 28 °C / Inert atmosphere 2: hydrogen / palladium 10% on activated carbon / water; methanol / 0.25 h / 19 - 54 °C / 1551.49 - 2327.23 Torr / Inert atmosphere View Scheme | |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide 2: hydrogen; palladium 10% on activated carbon / methanol View Scheme | |
| Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide; isopropyl alcohol / 20 - 60 °C 1.2: 20 °C 2.1: zinc; acetic acid / water / 2 h / 10 - 20 °C View Scheme |
