938066-21-8Relevant articles and documents
MTA-Cooperative PRMT5 Inhibitors
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Paragraph 0302, (2021/03/19)
The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Pyrazole-based ligands for the [copper-TEMPO]-mediated oxidation of benzyl alcohol to benzaldehyde and structures of the Cu coordination compounds
Uber, Jorge Salinas,Vogels, Yorick,Van Den Helder, Dave,Mutikainen, Ilpo,Turpeinen, Urho,Fu, Wen Tian,Roubeau, Olivier,Gamez, Patrick,Reedijk, Jan
, p. 4197 - 4206 (2008/03/14)
New pyrazole-based ligands have been designed, and the catalytic performances of their copper(II) complexes for the [copper/TEMPO]-mediated oxidation of benzyl alcohol to benzaldehyde have been examined. The pyridine-pyrazole ligands give efficient catalysts, while the use of naphthol-pyrazole ligands results in inactive catalytic systems. Single-crystals of four Cu coordination compounds obtained from pyridine-pyrazole ligands and a free ligand have been isolated and were characterized by X-ray diffraction. Thus, the solid-state structures of three copper(II) complexes are described, together with a copper(I) coordination chain, exhibiting luminescent properties. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.