885590-99-8

Basic information

• Product Name: 2,3-DIFLUORO-4-IODOBENZALDEHYDE
• Synonyms: 2,3-DIFLUORO-4-IODOBENZALDEHYDE
• CAS NO: 885590-99-8
• Molecular Formula: C₇H₃F₂IO
• Molecular Weight: 267.9993964
• Product Categories: Liquid Crystal intermediates
• Mol File: 885590-99-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 261.7°C at 760 mmHg
• Flash Point: 112.1°C
• Appearance: /
• Density: 2.036g/cm³
• Vapor Pressure: 0.0113mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(885590-99-8)
• EPA Substance Registry System: 2,3-DIFLUORO-4-IODOBENZALDEHYDE(885590-99-8)

Safety Data

• Hazardous Substances Data: 885590-99-8(Hazardous Substances Data)

Usage

General Description

2,3-Difluoro-4-iodobenzaldehyde is a chemical compound with the formula C7H3F2IO. It is a bright yellow solid that is commonly used in organic synthesis and pharmaceutical research. It is a versatile building block and intermediate in the production of various pharmaceuticals and agrochemicals. 2,3-Difluoro-4-iodobenzaldehyde is also used in the manufacture of electronic materials and can serve as a reagent in the preparation of other fluorinated aromatic compounds. This chemical compound is known for its reactivity and ability to undergo various chemical transformations, making it a valuable tool for synthetic chemists.

InChI:InChI=1/C7H3F2IO/c8-6-4(3-11)1-2-5(10)7(6)9/h1-3H

Upstream product

• 885590-98-7 2-(2,3-difluoro-4-iodophenyl)[1,3]dioxolane 

Downstream Products

• 885591-00-4 (2,3-difluoro-4-iodo-phenyl)-trimethylsilanyloxy-acetonitrile 

Relevant articles and documents

7-Fluoroindazoles as potent and selective inhibitors of factor Xa

We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor Xa inhibitors. The structure of a factor Xa cocrystal containing 7-fluoroindazole 51a showed the 7-fluoro atom hydrogen-bonding with the N-H of Gly216 (2.9 ?) in the peptide backbone. Thus, the 7-fluoroindazolyl moiety not only occupied the same space as the carbonyl group of an amide found in prior factor Xa inhibitors but also maintained a hydrogen bond interaction with the protein's β-sheet domain. The structure-activity relationship for this series was consistent with this finding, as the factor Xa inhibitory potencies were about 60-fold greater (ΔΔG ≈ 2.4 kcal/mol) for the 7-fluoroindazoles 25a and 25c versus the corresponding indazoles 25b and 25d. Highly convergent synthesis of these factor Xa inhibitors is also described.