2,3-DIFLUORO-4-IODOBENZALDEHYDE

Base Information

• Chemical Name: 2,3-DIFLUORO-4-IODOBENZALDEHYDE
• CAS No.: 885590-99-8
• Molecular Formula: C7H3F2IO
• Molecular Weight: 268.002
• Hs Code.: 2913000090
• Mol file: 885590-99-8.mol

Synonyms:2,3-DIFLUORO-4-IODOBENZALDEHYDE

Chemical Property of 2,3-DIFLUORO-4-IODOBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0113mmHg at 25°C
• Boiling Point: 261.7°C at 760 mmHg
• Flash Point: 112.1°C
• PSA: 17.07000
• Density: 2.036g/cm³
• LogP: 2.38190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Difluoro-4-iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIFLUORO-4-IODOBENZALDEHYDE

There total 1 articles about 2,3-DIFLUORO-4-IODOBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,3-difluoro-4-iodophenyl)[1,3]dioxolane (885590-98-7) → 2,3-difluoro-4-iodobenzaldehyde (885590-99-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; Heating / reflux;

Reference yield: 23.8%

2,3-difluoro-4-iodobenzaldehyde (885590-99-8) + 1-(2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl)piperidin-4-amine (924365-20-8) → N-(2,3-difluoro-4-iodobenzyl)-1-(2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl)piperidin-4-amine

Guidance literature:

2,3-difluoro-4-iodobenzaldehyde; 1-(2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl)piperidin-4-amine; With acetic acid; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 16h;

DOI:10.1021/acsmedchemlett.1c00345

Reference yield:

2,3-difluoro-4-iodobenzaldehyde (885590-99-8) + trimethylsilyl cyanide (7677-24-9) → (2,3-difluoro-4-iodo-phenyl)-trimethylsilanyloxy-acetonitrile (885591-00-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h;

upstream raw materials:

2-(2,3-difluoro-4-iodophenyl)[1,3]dioxolane

Downstream raw materials:

(2,3-difluoro-4-iodo-phenyl)-trimethylsilanyloxy-acetonitrile

Refernces

• 1、 -. "FACTOR XA COMPOUNDS". Page/Page column 40. . Retrieved 2008/06/13.