87421-27-0Relevant articles and documents
Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision
Melikhova, Ekaterina Y.,Pullin, Robert D. C.,Winter, Christian,Donohoe, Timothy J.
supporting information, p. 9753 - 9757 (2016/08/10)
The total synthesis of dehydromicrosclerodermin B and microsclerodermin J is described. Efficient approaches to the unusual amino acids in the target molecules were developed on the basis of a Negishi coupling (for Trp-2-CO2H) and Blaise reaction (for Pyrr). An incorrect assignment of the pyrrolidinone stereochemistry of both compounds was confirmed by synthesizing epimers of the proposed structures. The spectroscopic data of these epimers were in complete agreement with those for the naturally derived material.
USE OF CSE INHIBITORS FOR THE TREATMENT OF CUTANEOUS INJURIES OR CONDITIONS AND SLEEP-RELATED BREATHING DISORDERS
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Paragraph 00431, (2014/02/16)
no abstract published
CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES
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Page/Page column 38-39, (2011/01/12)
The present invention relates to compounds capable of inhibiting and/or decreasing the activity of one or more cathepsins, thereby treating and/or preventing various disease states associated with one or more cysteine proteases including, but not limited