817166-73-7Relevant articles and documents
High-Fidelity Sequence-Selective Duplex Formation by Recognition-Encoded Melamine Oligomers
Ballester, Pablo,Bolgar, Peter,Hunter, Christopher A.,Troselj, Pavle
, p. 8669 - 8678 (2021/06/28)
Melamine oligomers composed of repeating triazine-piperidine units and equipped with phenol and phosphine oxide side-chains form H-bonded duplexes. The melamine backbone provides sufficient rigidity to prevent intramolecular folding of oligomers up to thr
Synthesis of the tripeptide domain of sanglifehrins using asymmetric phase-transfer catalysis
White, James D.,Suttisintong, Khomson
, p. 2757 - 2762 (2013/04/23)
The tripeptide (S)-valinyl-(S)-m-hydroxyphenylalanyl-(3S)-piperazate common to immunosuppressant sanglifehrins was synthesized from the constituent amino acid residues in nine steps and 42% overall yield. A key construction was the installation of (S) absolute configuration in m-hydroxyphenylalanine using asymmetric phase-transfer catalysis in the presence of N-(1-naphthyl) cinchonidinium bromide. Cbz-protected (S)-valine was first coupled to the amino group of (S)-m-triisopropylsilyloxyphenylalanine tert-butyl ester, and the resulting dipeptide after ester cleavage was linked to (3S)-methyl piperazate.
From solution-phase to solid-phase enyne metathesis: Crossover in the relative performance of two commonly used ruthenium pre-catalysts
Brittain, Dominic E.A.,Lawrence Gray,Schreiber, Stuart L.
, p. 5086 - 5093 (2007/10/03)
A crossover in the ability of two distinct ruthenium-based metathesis pre-catalysts to effect the synthesis of dialkenylboronic esters in solution and on the solid-phase was observed. Specifically, while the Grubbs 2nd generation pre-catalyst 3 affords a
