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80465-12-9

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80465-12-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80465-12-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,4,6 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80465-12:
(7*8)+(6*0)+(5*4)+(4*6)+(3*5)+(2*1)+(1*2)=119
119 % 10 = 9
So 80465-12-9 is a valid CAS Registry Number.

80465-12-9Downstream Products

80465-12-9Relevant articles and documents

A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy

Zhang, Chunyan,Liang, Zuyu,Jia, Xiaofei,Wang, Maorong,Zhang, Guoying,Hu, Mao-Lin

supporting information, p. 14215 - 14218 (2020/11/24)

A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner. This journal is

Development of novel liver?X?receptor modulators based on a 1,2,4-triazole scaffold

Goher, Shaimaa S.,Griffett, Kristine,Hegazy, Lamees,Elagawany, Mohamed,Arief, Mohamed M.H.,Avdagic, Amer,Banerjee, Subhashis,Burris, Thomas P.,Elgendy, Bahaa

, p. 449 - 453 (2019/01/04)

Liver X Receptor (LXR) agonists have been reported as a potential treatment for atherosclerosis, Alzheimer's disease and hepatitis C virus (HCV) infection. We have designed and synthesized a series of potent compounds based on a 1,2,4-triazole scaffold as novel LXR modulators. In cell-based cotransfection assays these compounds generally functioned as LXR agonists and we observed compounds with selectivity towards LXRα (7-fold) and LXRβ (7-fold) in terms of potency. Assessment of the effects of selected compounds on LXR target gene expression in HepG2 cells revealed that compounds 6a-b and 8a-b behaved as inverse agonists on FASN expression even though they were agonists in the LXRα and LXRβ cotransfection assays. Interestingly, these compounds had no effect on the expression of SREBP-1c confirming a unique LXR modulator pharmacology. Molecular docking studies and evaluation of ADME properties in-silico show that active compounds possess favorable binding modes and ADME profiles. Thus, these compounds may be useful for in vivo characterization of LXR modulators with unique profiles and determination of their potential clinical utility.

Multi-nitrogen compound and its synthetic method

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Paragraph 0032; 0065-0068, (2017/02/24)

The invention relates to a multi-nitrogen compound and a synthesis method thereof. The synthesis method is a synthesis method of a multi-nitrogen heterocyclic compound employing copper acetate to participate into multi-component reaction of 2,3- allenoic

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