1073-62-7

Basic information

• Product Name: BENZYLHYDRAZINE MONOHYDROCHLORIDE
• Synonyms: BENZYLHYDRAZINE HCL;BENZYLHYDRAZINE HYDROCHLORIDE;BENZYLHYDRAZINE MONOHYDROCHLORIDE;(phenylmethyl)hydrazinemonohydrochloride;(phenylmethyl)-hydrazinmonohydrochloride;benzyl-hydrazinhydrochloride;p1297;usafel-54
• CAS NO: 1073-62-7
• Molecular Formula: C₇H₁₀N₂*ClH
• Molecular Weight: 158.63
• EINECS: 1312995-182-4
• Mol File: 1073-62-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 113 °C
• Boiling Point: 265.4 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: /
• Density: 1.033 g/cm³
• Vapor Pressure: 0.00918mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol, Water
• Water Solubility: almost transparency
• CAS DataBase Reference: BENZYLHYDRAZINE MONOHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYLHYDRAZINE MONOHYDROCHLORIDE(1073-62-7)
• EPA Substance Registry System: BENZYLHYDRAZINE MONOHYDROCHLORIDE(1073-62-7)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S36:
• RIDADR: 2811
• RTECS: MU8575000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1073-62-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BENZYLHYDRAZINE MONOHYDROCHLORIDE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its mutagenic properties make it a valuable component in the development of drugs that target specific biological pathways.
Used in Chemical Research:
In the field of chemical research, BENZYLHYDRAZINE MONOHYDROCHLORIDE serves as a key substance for studying the properties and reactions of arylhydrazine derivatives. This aids in understanding their behavior and potential applications in different chemical processes.
Used in Organic Synthesis:
BENZYLHYDRAZINE MONOHYDROCHLORIDE is utilized as a reagent in organic synthesis, particularly for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, contributing to the synthesis of complex organic molecules.
Used in Analytical Chemistry:
In analytical chemistry, BENZYLHYDRAZINE MONOHYDROCHLORIDE can be employed as a reference compound for the development and calibration of analytical methods. Its distinct properties make it suitable for use in the validation of techniques and instruments in this field.

Safety Profile

Poison by ingestion andintraperitoneal route. When heated to decomposition itemits very toxic fumes of NOx and Cl-.

InChI:InChI=1/C7H12N2/c8-9-6-7-4-2-1-3-5-7/h1-5H,6,9H2,8H3/q+2

Upstream product

• 100-52-7 benzaldehyde 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 100-51-6 benzyl alcohol 
• 287729-00-4 N-benzyl-N-tert-butyloxycarbonylaminophthalimide 
• 185456-43-3 N-benzyl-N’-[(tert-butoxy)carbonyl](tert-butoxy)carbohydrazide 
• 147688-34-4 tert-butyl 1-benzylhydrazine-1-carboxylate 
• 13211-11-5 benzaldehyde benzylhydrazone 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 

Downstream Products

• 81468-07-7 3-(3-benzyl-thiocarbazoyl-thio)-propionsaeure 
• 654058-90-9 methyl 5-(4-methylthiophenyl)-1-benzylpyrazole-3-carboxylate 
• 674790-23-9 N-tert-butoxycarbonyl-β-(2-benzyl-4,5,6,7-tetrahydroindazol-3-yl)-L-alanine α-tert butyl ester 
• 674790-29-5 β-(1-benzyltetrahydroindazol-3-yl)alanine 
• 674790-32-0 4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester 
• 674790-35-3 2-amino-3-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-propionic acid 
• 674790-38-6 2-amino-4-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-butyric acid 
• 213837-48-0 2-(1-benzylhydrazino)-4-methylthiazole-5-carboxylic acid 
• 213837-43-5 ethyl 2-(1-benzyl)hydrazino-4-methylthiazole-5-carboxylate 
• 213837-42-4 ethyl 2-(1-benzyl-2-benzylidene)hydrazino-4-methylthiazole-5-carboxylate 

Relevant articles and documents

Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis

We report the cerium photocatalyzed radical decarboxylative hydrazination of carboxylic acids with di-tert-butylazodicarboxylate (DBAD). The operationally simple protocol provides rapid access to synthetically useful hydrazine derivatives and overcomes current scope limitations in the photoredox-catalyzed decarboxylation of carboxylic acids.

Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

A series of N1- and N2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N1- and N2-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.

N-tert-butoxycarbonylaminophthalimide, a versatile reagent for the conversion of alcohols into alkylated tert-butylcarbazates or hydrazines via the Mitsunobu protocol

An efficient two-step method has been developed for the conversion of alcohols to substituted hydrazines. The use of N-tert- butoxycarbonylaminophthalimide as an acid partner in Mitsunobu reactions with a variety of alcohols permits the synthesis of the corresponding monoalkylated tert-butylcarbazates and hydrazines.