757242-20-9

Basic information

• Product Name: (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid
• CAS NO: 757242-20-9
• Molecular Weight: 577.737
• Mol File: 757242-20-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid(757242-20-9)
• EPA Substance Registry System: (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid(757242-20-9)

Safety Data

• Hazardous Substances Data: 757242-20-9(Hazardous Substances Data)

Upstream product

• 171348-52-0 2-((tert-butoxycarbonyl)amino)-3-fluoro-3-methylbutanoic acid 
• 228266-38-4 N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine 
• 43163-94-6 2-amino-3-fluoro-3-methylbutanoic acid 

Relevant articles and documents

Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents

Modifications of the B-segment of HTI-286 (2) produced a class of analogs incorporating heteroatom-substituents. The structure-activity relationship was studied. Analogs bearing methylsulfide and fluoride groups exhibited potency comparable to that of the parent compound HTI-286 and to paclitaxel in cytotoxicity assays against KB-3-1 cell lines. These analogs were more potent than paclitaxel against P-glycoprotein expressing KB-8-5 and KB-V1 cell lines. Several analogs showed strong inhibition of tubulin polymerization.