7464-51-9

Basic information

• Product Name: 4-methoxy-N-(2-methylpropyl)benzamide
• CAS NO: 7464-51-9
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.2689
• Mol File: 7464-51-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 352.7°C at 760 mmHg
• Flash Point: 167.1°C
• Density: 1.017g/cm³
• Vapor Pressure: 3.77E-05mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 4-methoxy-N-(2-methylpropyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(2-methylpropyl)benzamide(7464-51-9)
• EPA Substance Registry System: 4-methoxy-N-(2-methylpropyl)benzamide(7464-51-9)

Safety Data

• Hazardous Substances Data: 7464-51-9(Hazardous Substances Data)

Upstream product

• 78-81-9 isobutylamine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 82938-20-3 3-methyl-1-(4-methoxyphenyl)-1-butanone 
• 7380-78-1 4-(phenylethynyl)anisole 
• 536-74-3 phenylacetylene 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 15226-74-1 dicobalt octacarbonyl 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 1557154-80-9 C₁₂H₁₅⁽²⁾H₂NO₂ 
• 1557154-83-2 C₁₉H₂₁NO₃ 
• 68055-21-0 N-Isobutyl-4-methoxy-thiobenzamide 

Relevant articles and documents

Photocatalyzed Triplet Sensitization of Oximes Using Visible Light Provides a Route to Nonclassical Beckmann Rearrangement Products

Oximes are valuable synthetic intermediates for the preparation of a variety of functional groups. To date, the stereoselective synthesis of oximes remains a major challenge, as most current synthetic methods either provide mixtures of E and Z isomers or furnish the thermodynamically preferred E isomer. Herein we report a mild and general method to achieve Z isomers of aryl oximes by photoisomerization of oximes via visible-light-mediated energy transfer (EnT) catalysis. Facile access to (Z)-oximes provides opportunities to achieve regio- and chemoselectivity complementary to those of widely used transformations employing oxime starting materials. We show an enhanced one-pot protocol for photocatalyzed oxime isomerization and subsequent Beckmann rearrangement that enables novel reactivity with alkyl groups migrating preferentially over aryl groups, reversing the regioselectivity of the traditional Beckmann reaction. Chemodivergent N- or O- cyclizations of alkenyl oximes are also demonstrated, leading to nitrones or cyclic oxime ethers, respectively.

Co2(CO)8 as a convenient in situ CO source for the direct synthesis of benzamides from aryl halides (Br/I) via aminocarbonylation

A fast, mild, and functional group tolerant method for the direct synthesis of benzamides from aryl halides (Br, I) via aminocarbonylation, using solid Co2(CO)8 as a convenient CO source, has been demonstrated. The developed method is applicable to a wide variety of 1 and cyclic and acyclic 2 amines. Nitro substituted (o, m and p) aryl halides have easily been converted to the corresponding benzamides, without the reduction of the nitro group, in high yields using this in situ carbonylation methodology under microwave irradiation.

The First ZnII-Catalyzed Oxidative Amidation of Benzyl Alcohols with Amines under Solvent-Free Conditions

The first zinc-catalyzed oxidative amidation of benzyl alcohols has been developed. Both aliphatic and aromatic amines can be tolerated and applied in this reaction. Various amides were prepared in good yields under solvent-free and mild conditions. Copyright