72398-40-4

Basic information

• Product Name: Benzoyl fluoride, 4-bromo- (9CI)
• Synonyms: Benzoyl fluoride, 4-bromo- (9CI)
• CAS NO: 72398-40-4
• Molecular Formula: C₇H₄BrFO
• Molecular Weight: 203.0084632
• Product Categories: ACIDHALIDE
• Mol File: 72398-40-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl fluoride, 4-bromo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl fluoride, 4-bromo- (9CI)(72398-40-4)
• EPA Substance Registry System: Benzoyl fluoride, 4-bromo- (9CI)(72398-40-4)

Safety Data

• Hazardous Substances Data: 72398-40-4(Hazardous Substances Data)

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 698-67-9 p-bromobenzamide 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 

Downstream Products

• 74834-46-1 3-(p-bromobenzoyl)-1,3-thiazolidine-2-thione 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 80311-89-3 4-bromo-N-benzylbenzamide 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Relevant articles and documents

Cooperative NHC/Photoredox Catalyzed Ring-Opening of Aryl Cyclopropanes to 1-Aroyloxylated-3-Acylated Alkanes

Cyclopropanes are an important class of building blocks in organic synthesis. Herein, a ring-opening/arylcarboxylation/acylation cascade reaction for the 1,3-difunctionalization of aryl cyclopropanes enabled by cooperative NHC and organophotoredox catalysis is reported. The cascade works on monosubstituted cyclopropanes that are in contrast to the heavily investigated donor–acceptor cyclopropanes more challenging to be difunctionalized. The key step is a radical/radical cross coupling of a benzylic radical generated in the photoredox catalysis cycle with a ketyl radical from the NHC catalysis cycle. The transformation features metal-free reaction conditions and tolerates a diverse range of functionalities.

Fluorination method

In order to overcome the problems of high cost and low stability of the existing fluorination reagents for preparing acyl fluoride, sulfonyl fluoride and phosphoryl fluoride compounds, the invention provides a fluorination method, which comprises the following operation steps of: adding a fluorination reagent into a substrate, wherein the fluorination reagent comprises cations M and anions, the anions are selected from one or more of perfluoropolyether chain carboxylic acid anions as shown in the specification: CF3(OCF2)nCO2, wherein n is selected from 1-10; the substrate comprises a carboxylic acid compound, a sulfonic acid compound, a phosphoric acid compound and a phosphine oxide compound; and carrying out fluorination reaction to obtain acyl fluoride, sulfonyl fluoride and phosphoryl fluoride products. According to the fluorination method provided by the invention, the perfluoropolyether chain carboxylate is used as a fluorination reagent, so that the dehydroxylation fluorination reaction of the carboxylic acid compound, the sulfonic acid compound and the phosphoric acid compound and the fluorination reaction of the phosphine oxide compound are realized, the product yield isrelatively high, and the fluorination method has relatively good universality for different substrates.

Cooperative NHC and Photoredox Catalysis for the Synthesis of β-Trifluoromethylated Alkyl Aryl Ketones

Despite the great potential of radical chemistry in organic synthesis, N-heterocyclic carbene (NHC)-catalyzed reactions involving radical intermediates are not well explored. This communication reports the three-component coupling of aroyl fluorides, styrenes and the Langlois reagent (CF3SO2Na) to give various β-trifluoromethylated alkyl aryl ketones with good functional group tolerance in moderate to high yields by cooperative photoredox/NHC catalysis. The alkene acyltrifluoromethylation proceeds via radical/radical cross coupling of ketyl radicals with benzylic C-radicals. The ketyl radicals are generated via SET reduction of in situ formed acylazolium ions whereas the benzylic radicals derive from trifluoromethyl radical addition onto styrenes.